MRS 2365

MRS 2365

MRS 2365;MRS 2365,[[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl]diphosphoricacidmonoestertrisodiumsalt;[[(1R,2R,3S,4R,5S)-4-[6-AMino-2-(Methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]Methyl]diphosphoricacidMonoestertrisodiuMsalt

436847-09-5

C₁₃H₁₆N₅O₉P₂S-₃^.₃[Na+]

549.28

P2Y1受体激动剂,A highly potent, selective P2Y1 receptor agonist with EC50 of 1.2 nM. <span class="highlight" style="box-sizing: border-box; font-weight: bold; color: #333333; font-family: arial, sans-serif; font-size: 14px;">化学名：</span><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">&nbsp;[[(1</span><em style="box-sizing: border-box; color: #333333; font-family: arial, sans-serif; font-size: 14px;">R</em><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">,2</span><em style="box-sizing: border-box; color: #333333; font-family: arial, sans-serif; font-size: 14px;">R</em><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">,3</span><em style="box-sizing: border-box; color: #333333; font-family: arial, sans-serif; font-size: 14px;">S</em><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">,4</span><em style="box-sizing: border-box; color: #333333; font-family: arial, sans-serif; font-size: 14px;">R</em><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">,5</span><em style="box-sizing: border-box; color: #333333; font-family: arial, sans-serif; font-size: 14px;">S</em><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">)-4-[6-Amino-2-(methylthio)-9</span><em style="box-sizing: border-box; color: #333333; font-family: arial, sans-serif; font-size: 14px;">H</em><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt</span> <strong><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">生物活性：</span></strong><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">MRS 2365 is a highly potent, selective P2Y</span><span style="box-sizing: border-box; position: relative; line-height: 0; vertical-align: baseline; bottom: -0.25em; color: #333333; font-family: arial, sans-serif;">1</span><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">&nbsp;receptor agonist (EC</span><span style="box-sizing: border-box; position: relative; line-height: 0; vertical-align: baseline; bottom: -0.25em; color: #333333; font-family: arial, sans-serif;">50</span><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">&nbsp;= 0.4 nM). Displays no activity at P2Y</span><span style="box-sizing: border-box; position: relative; line-height: 0; vertical-align: baseline; bottom: -0.25em; color: #333333; font-family: arial, sans-serif;">12</span><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">&nbsp;receptors and only very low agonist activity at P2Y</span><span style="box-sizing: border-box; position: relative; line-height: 0; vertical-align: baseline; bottom: -0.25em; color: #333333; font-family: arial, sans-serif;">13</span><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">&nbsp;receptors (at concentrations up to 1&nbsp;</span><span class="symbol" style="box-sizing: border-box; color: #333333; font-family: arial, sans-serif; font-size: 14px;">&mu;</span><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">M). Increases the upregulation of NTPDase1 by ATP</span><span class="symbol" style="box-sizing: border-box; color: #333333; font-family: arial, sans-serif; font-size: 14px;">&gamma;</span><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">S.</span> <strong><span style="color: #333333; font-family: arial, sans-serif; font-size: 14px;">技术参数：</span></strong> <span style="color: #333333; font-family: arial, sans-serif;"><span style="font-size: 14px;">分子量549.28</span></span> <span style="color: #333333; font-family: arial, sans-serif;"><span style="font-size: 14px;">公式&nbsp; &nbsp; &nbsp; &nbsp; C13H16N5O9P2SNa3</span></span> <span style="color: #333333; font-family: arial, sans-serif;"><span style="font-size: 14px;">储存&nbsp; &nbsp; &nbsp; &nbsp; Store at -20&deg;C</span></span> <span style="color: #333333; font-family: arial, sans-serif;"><span style="font-size: 14px;">纯度&nbsp; &ge;98% (HPLC)</span></span> <span style="color: #333333; font-family: arial, sans-serif;"><span style="font-size: 14px;">溶解性Soluble in water (supplied pre-dissolved at a concentration of 10mM)</span></span> <span style="color: #333333; font-family: arial, sans-serif;"><span style="font-size: 14px;">外观&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Colourless liquid</span></span> <span style="color: #333333; font-family: arial, sans-serif;"><span style="font-size: 14px;">Solubility&nbsp; Soluble in water (supplied pre-dissolved at a concentration of 10mM)&nbsp;</span></span> <span style="color: #333333; font-family: arial, sans-serif;"><span style="font-size: 14px;">Storage&nbsp; &nbsp; Store at -20&deg;C</span></span> <strong>参考文献</strong> <p style="box-sizing: border-box; margin: 0px 0px 10px; font-size: 14px; color: #333333; font-family: arial, sans-serif;"><span class="highlight" style="box-sizing: border-box; font-weight: bold;">Ravi</span>&nbsp;<em style="box-sizing: border-box;">et al</em>&nbsp;(2002)&nbsp;<a style="box-sizing: border-box; background-color: transparent; text-decoration-line: none; color: #7092b1 !important;" title="View abstract" href="https://www.ncbi.nlm.nih.gov/pubmed/11985476" rel="nofollow" target="_blank">Adenine nucleotide analogues locked in a northern methanocarba conformation: enhanced stability and potency as P2Y<span style="box-sizing: border-box; position: relative; font-size: 12px; line-height: 0; vertical-align: baseline; bottom: -0.25em;">1</span>&nbsp;receptor agonists.&nbsp;</a>J.Med.Chem.&nbsp;<span style="box-sizing: border-box; font-weight: bold;"><em style="box-sizing: border-box;">45</em></span>&nbsp;2090 PMID:&nbsp;11985476 <p style="box-sizing: border-box; margin: 0px 0px 10px; font-size: 14px; color: #333333; font-family: arial, sans-serif;"><span class="highlight" style="box-sizing: border-box; font-weight: bold;">Chhatriwala</span>&nbsp;<em style="box-sizing: border-box;">et al</em>&nbsp;(2004)&nbsp;<a style="box-sizing: border-box; background-color: transparent; text-decoration-line: none; color: #7092b1 !important;" title="View abstract" href="https://www.ncbi.nlm.nih.gov/pubmed/15345752" rel="nofollow" target="_blank">Induction of novel agonist selectivity for the ADP-activated P2Y<span style="box-sizing: border-box; position: relative; font-size: 12px; line-height: 0; vertical-align: baseline; bottom: -0.25em;">1</span>&nbsp;receptor versus the ADP-activated P2Y<span style="box-sizing: border-box; position: relative; font-size: 12px; line-height: 0; vertical-align: baseline; bottom: -0.25em;">12</span>&nbsp;and P2Y<span style="box-sizing: border-box; position: relative; font-size: 12px; line-height: 0; vertical-align: baseline; bottom: -0.25em;">13</span>&nbsp;receptors by conformational constraint of an ADP analog.&nbsp;</a>J.Pharmacol.Exp.Ther.&nbsp;<span style="box-sizing: border-box; font-weight: bold;"><em style="box-sizing: border-box;">311</em></span>&nbsp;1038 PMID:&nbsp;15345752 <p style="box-sizing: border-box; margin: 0px 0px 10px; font-size: 14px; color: #333333; font-family: arial, sans-serif;"><span class="highlight" style="box-sizing: border-box; font-weight: bold;">Lu</span>&nbsp;<em style="box-sizing: border-box;">et al</em>&nbsp;(2007)&nbsp;<a style="box-sizing: border-box; background-color: transparent; text-decoration-line: none; color: #7092b1 !important;" title="View abstract" href="https://www.ncbi.nlm.nih.gov/pubmed/17626796" rel="nofollow" target="_blank">Stimulation of the P2Y<span style="box-sizing: border-box; position: relative; font-size: 12px; line-height: 0; vertical-align: baseline; bottom: -0.25em;">1</span>&nbsp;receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells.&nbsp;</a>J.Pharmacol.Exp.Ther.&nbsp;<span style="box-sizing: border-box; font-weight: bold;"><em style="box-sizing: border-box;">323</em></span>&nbsp;157 PMID:&nbsp;17626796 <p style="box-sizing: border-box; margin: 0px 0px 10px; font-size: 14px; color: #333333; font-family: arial, sans-serif;"><span style="color: #333333; font-family: arial, sans-serif;"><span style="font-size: 14px;">查询关键词：<strong>&ldquo;436847-09-5，MRS 2365，PC10886，</strong></span></span><strong><span style="font-size: 14px; color: #333333; font-family: arial, sans-serif;">Medlife，上海现货</span><span style="font-size: 14px; color: #333333; font-family: arial, sans-serif;">&rdquo;。</span></strong>