469-59-0|Jervine，≥98%|Medlife为MCE，Selleck，麦克林，阿拉丁试剂，罗恩试剂，Sigma，安耐吉试剂，泰坦等同类产品品牌，上海现货，性价比高

您当前的位置：

Jervine

Hedgehog信号抑制剂,Jervine(11-Ketocyclopamine)是甾体类生物碱，能阻断sonic hedgehog(Shh)信号通路，抑制Smo。

目录号: PC15845 纯度: ≥98%

CAS No. :469-59-0

商品编号	规格	价格	会员价
PC15845-5mg	5mg	¥1366.12	请登录
PC15845-10mg	10mg	¥2459.80	请登录
PC15845-50mg	50mg	¥9843.12	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称

Jervine

中文别名

介芬胺;介藜芦碱;蒜黎芦碱;白藜芦碱;杰尔碱;杰尔文;介芬碱;芥芬鹼;蒜藜芦碱;Jervine 蒜藜芦碱;介芬胺蒜藜芦碱介藜芦胺;芥芬胺;芥芬胺、蒜藜芦碱、介藜芦胺;藜芦胺;介藜芦胺;蒜藜芦碱.介藜芦胺

英文名称

Jervine

英文别名

JERVINE;(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one;jerwiny;Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)-pyridin)-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-;spiro(9h-benzo(a)fluorene-9,2’(3’h)-furo(3,2-b)-pyridin)-11(1h)-one,2,3,3’a,4,;Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3beta,23beta)-;11-KETOCYCLOPAMINE;(3BETA, 23BETA)-17,23-EPOXY-3-HYDROXYVERATRAMAN-11-ONE;JERVINE(P);Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,...;Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydr;(3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one;DL-ISOLEUCINE GRADE II;Iervin;Jervin-11-one;(3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one;Jerwiny [Polish];C27H39NO3;19V3ECX465;NSC23898;NSC7520

Cas No.

469-59-0

分子式

C₂₇H₃₉NO₃

分子量

425.60

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties.

性状

Solid

IC50 & Target[1][2]

IC50: 500-700 nM (Hedgehog)

体外研究(In Vitro)

Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation.
Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	HEL and TF1a cells
Concentration:	40 μM
Incubation Time:	6, 12 and 24 hours
Result:	Inhibited Akt phosphorylation.

体内研究(In Vivo)

Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague Dawley rats (180-200? g)
Dosage:	50, 100, 200 and 400? mg/kg
Administration:	Orally
Result:	Exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

结构分类

来源

参考文献

[1]. Williams JA, et al.Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basalcell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21. [Information]

[2]. Dumlu FA, et al.Anti-inflammatory and antioxidant properties of jervine, a sterodial alkaloid from rhizomes of Veratrum album.Phytomedicine. 2019 Mar 1;55:191-199. [Information]

[3]. Ghezali L, et al.Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect.Exp Cell Res. 2013 Apr 15;319(7):1043-53. [Information]

溶解度数据

体外研究:

DMSO : 1 mg/mL (2.35 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3496 mL	11.7481 mL	23.4962 mL
5 mM	---	---	---
10 mM	---	---	---

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation