可溶性鸟苷酸环化酶(sGC)的氧化(无血红素)形式的活化剂,Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC.
Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects.
性状
Solid
IC50 & Target[1][2]
soluble guanylate cyclase
体外研究(In Vitro)
Ataciguat (1-100 μM) induces the relaxation in aortic rings or coronary rings.
Ataciguat (0.1-10 μM; 30 min) increases NO production in HUVEC cells.
Ataciguat (1 nM-100 μM) induces concentration-dependent relaxations in sphincter of Oddi (SO) rings pre-contracted by Carbachol.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.