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DL-α-Hydroxyglutaric acid disodium salt

α羟基酸,D-α-Hydroxyglutaric acid（D-α-羟基戊二酸）是一种由（R）-5-氧代-2-四氢呋喃羧酸水解形成的α-羟基酸，在人类神经代谢疾病D-α-羟基戊二酸尿症中过量产生。

目录号: PC12464 纯度: ≥98%

CAS No. :40951-21-1

商品编号	规格	价格	会员价
PC12464-25mg	25mg	¥1274.00	请登录
PC12464-50mg	50mg	¥1940.40	请登录
PC12464-100mg	100mg	¥2548.00	请登录

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中文名称	DL-α-Hydroxyglutaric acid disodium salt
中文别名	DL-Α-羟基戊二酸二钠;2-羟基戊二酸;DL-Alpha-羟基戊二酸二钠;莫格他唑
英文名称	DL-α-Hydroxyglutaric acid disodium salt
英文别名	Pentanedioic acid,2-hydroxy-, sodium salt (1:2);2-HYDROXYGLUTARIC ACID;α-Hydroxyglutaric Acid (sodium salt);(RS)-2-Hydroxypentanedioic acid disodium salt Disodium 2-hydroxyglutarate;(RS)-2-Hydroxypentanedioic acid disodium salt;Disodium 2-hydroxyglutarate;disodium 2-hydroxypentanedioate;D-2-Hydroxypentanedioic acid disodium salt;Disodium (R)-2-Hydroxyglutarate;L-2-hydroxyglutaric acid disodium salt;alpha-Oxyglutarate sodium;Sodium alpha-hydroxyglutarate;2-Hydroxypentanedioic acid sodium salt;2-Hydroxyglutaric acid sodium salt;Di-sodium salt of L-alpha-oxyglutaric acid;disodium;(2S)-2-hydroxypentanedioate;Glutaric acid, 2-hydroxy-, disodium salt, L-alpha-;sodium 2-hydroxyglutarate;disodium
Cas No.	40951-21-1
分子式	C₅H₆Na₂O₅
分子量	192.08
包装储存	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.

性状

Solid

IC50 & Target[1][2]

Microbial Metabolite

Human Endogenous Metabolite

体外研究(In Vitro)

Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium, respectively.
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium inhibits the activity of TET 5-methylcytosine hydroxylases.
Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) disodium increases HIF-1α and decreases endostatin.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

结构分类

Ketones, Aldehydes, Acids

参考文献

[1]. Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30. [Information]

溶解度数据

体外研究:

H₂O : 125 mg/mL (650.77 mM; ultrasonic and warming and heat to 60°C)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.2062 mL	26.0308 mL	52.0616 mL
5 mM	1.0412 mL	5.2062 mL	10.4123 mL
10 mM	0.5206 mL	2.6031 mL	5.2062 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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