Labetalol|36894-69-6|(AH5158; Sch-15719W free base)-陌孚医药/Medlife

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Labetalol (Synonyms: AH5158; Sch-15719W free base)

目录号: PL14291 纯度: ≥99%

CAS No. :36894-69-6

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PL14291-200mg	200mg	询价	询价
PL14291-500mg	500mg	询价	询价

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中文名称	Labetalol
中文别名	柳胺苄心定;拉本他乐;降压乐;拉贝洛尔;拉贝洛尔标准品;2-羟基-5-{1-羟基-2-[(1-甲基-3-苯基丙基)氨基]乙基}苯甲酰胺
英文名称	Labetalol
英文别名	2-Hydroxy-5-(1-hydroxy-2-((4-phenylbutan-2-yl)amino)ethyl)benzamide;5-[1-HYDROXY-2-[(1-METHYL-3-PHENYLPROPYLAMINO)ETHYL]]SALICYLAMIDE;LABETALOL;rac Labetalol;2-Hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide;Labetolol;Albetol;Ibidomide;Labetalolum;Normodyne;Trandate;Labetalolum [INN-Latin];Labetalol [INN:BAN];AH 5158;5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide;2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide;ScH 15719W;3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol;SGUAFYQXFOLMHL-UHFFFAO;Labetalol
Cas No.	36894-69-6
分子式	C₁₉H₂₄N₂O₃
分子量	328.41
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Labetalol (AH5158) 是一种具有口服活性的选择性 α1- 和非选择性 β-肾上腺素能受体 (adrenergic receptor) 竞争性拮抗剂。Labetalol 是一种抗高血压药物，可用于心血管疾病的研究，如妊娠期高血压。

生物活性

Labetalol (AH5158) is an orally active selective α1- and non-selective β-adrenergic receptors competitive antagonist. Labetalol, an anti-hypertensive agent, can be used for the research of cardiovascular disease, such as hypertension in pregnancy.

性状

Solid

IC50 & Target[1][2]

α1-adrenergic receptor β-adrenoceptor

体外研究(In Vitro)

Labetalol exhibits greater affinity for β-adrenergic sites on guinea pig heart and lung membranes (IC50=0.8 and 4.0 μM respectively) .
Labetalol has affinity for α-adrenergic binding sites (IC50=15 uM) on rabbit uterine membranes.Labctalol has 19 times greater binding affinity for β binding sites in heart membranca than α binding sites in uterine membranes. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Labetalol (10 mg/kg; i.h.) passes the blood-brain barrier, reaching a level of 2.1 ug/g tissue in the 10-day-old rat pups brain 90 min after injection. Labetalol (5.0 mg/kg; i.p.) attenuates circulating IL-1β and IL-6 in tailshock stress rats. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Brogden RN, et al. Labetalol: a review of its pharmacology and therapeutic use in hypertension. Drugs. 1978;15(4):251-270.
[2]. Greenslade FC, et al. Labetalol binding to specific alpha- and beta-adrenergic sites in vitro and its antagonism of adrenergic responses in vivo. J Mol Cell Cardiol. 1979 Aug;11(8):803-11.

溶解度数据	In Vitro: DMSO : 125 mg/mL (380.62 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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