Metaproterenol hemisulfate|5874-97-5|(Orciprenaline hemisulfate)-陌孚医药/Medlife

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Metaproterenol hemisulfate (Synonyms: Orciprenaline hemisulfate)

目录号: PL14302 纯度: ≥99%

CAS No. :5874-97-5

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中文名称	Metaproterenol hemisulfate
中文别名	Metaproterenol hemisulfate
英文名称	Metaproterenol hemisulfate
英文别名	Metaproterenol hemisulfate
Cas No.	5874-97-5
分子式	C₁₁H₁₇NO₃^.₀^.₅H₂O₄S
分子量	260.30
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Metaproterenol hemisulfate (Orciprenaline hemisulfate) 是一种直接作用的拟交感神经药，是 β2-肾上腺素能受体 (β2AR) 激动剂，其 IC₅₀ 为 68 nM。Metaproterenol hemisulfate 还具有抗炎活性。
生物活性	Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC 50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity.
性状	Solid
IC50 & Target[1][2]	IC50: 68 nM (β2-adrenergic receptor)
体外研究(In Vitro)	Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages. Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Noh H, et al. Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications. Kidney Int. 2017 Jul;92(1):101-113. [2]. Ibrahim FA, et al. Highly sensitive spectrofluorimetric method for rapid determination of orciprenaline in biological fluids and pharmaceuticals. Luminescence. 2019 Feb;34(1):77-83.

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (240.11 mM; Need ultrasonic)配制储备液

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