Practolol|6673-35-4|(普拉洛尔)-陌孚医药/Medlife

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Practolol (Synonyms: 普拉洛尔)

目录号: PL14276 纯度: ≥99%

CAS No. :6673-35-4

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PL14276-500mg	500mg	询价	询价

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中文名称	Practolol
中文别名	普拉洛尔;心得宁;醋心安;醋氨心安;(S)-3-甲基-2-苯基丁胺;N-[4-[2-羟基-3-[(1-甲基乙基)氨基]丙氧基]苯基]乙酰胺
英文名称	Practolol
英文别名	N-(4-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide;Practolol [USAN:INN:BAN];Practolol;1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol;4'-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide;AY 21011;Acetamide, N-(4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-;CCRIS 1089;Dalzic;Eraldin;ICI 50172;N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide;Practololo;Practololo [DCIT];Practololum;Practololum [INN-Latin];Praktololu;Praktololu [Polish];Teranol;UNII-SUG9176GRW;Acetanilide, 4'-(2-hydroxy-3-(isopropylamino)propoxy)-;rac Practolol;2243398;N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide;(±)-Practolol;4′-[2-Hydroxy-3-(isopropylamino)propoxy]acetanilidex;N-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide;Acetanilide,4'-[2-hydroxy-3-(isopropylamino)propoxy]- (7CI,8CI);(?à)-Practolol;4'-[2-Hydroxy-3-(isopropylamino)propoxy]acetanilide;DL-4'-[2-Hydroxy-3-(isopropylamino)propoxy]acetanilide;Racemic Practolol;dl-Practolol;ICI50172
Cas No.	6673-35-4
分子式	C₁₄H₂₂N₂O₃
分子量	266.34
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Practolol 是一种有效和选择性的 β1 肾上腺素能受体拮抗剂。Practolol 可用于心律失常的研究。
生物活性	Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias.
性状	Solid
IC50 & Target[1][2]	β1-adrenergic receptor
体外研究(In Vitro)	Practolol (10 μM; 30 min) preferentially antagonizes the relaxant effects produced by R0363 in spontaneously contracted tracheal preparations from the guinea-pig. Practolol (10 nM-100 μM) blocks the progesterone production induced by (-)epinephrine in a dose-dependent manner in granulosa cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Practolol (0.5 mg/kg; i.v.) decreases heart rate, left ventricular dP/dt max, myocardial blood flow and cardiac output in intact close-chest dogs. Practolol (0.5 mg/kg; i.v.) decreases normal myocardial blood flow but flow in the ischaemic area remains unchanged after coronary artery ligation. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Iakovidis D, et, al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68(4):677-85. [2]. Adashi EY, et, al. Stimulation of beta 2-adrenergic responsiveness by follicle-stimulating hormone in rat granulosa cells in vitro and in vivo. Endocrinology. 1981 Jun;108(6):2170-8.

溶解度数据	In Vitro: DMSO : 100 mg/mL (375.46 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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