Betaxolol 盐酸盐是 β1 肾上腺素受体 (beta1 adrenergic receptor) 阻断剂，可用于高血压和青光眼的研究。

Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

Solid

Beta1 Adrenergic Receptor

Betaxolol hydrochloride is a cardioselective beta-adrenergic receptor blocking agent. has not independently confirmed the accuracy of these methods. They are for reference only.

Betaxolol hydrochloride (5 mg/kg via i.p. injection) was administered at 24 and then 44 h following the final chronic cocaine administration. Animals treated with betaxolol during cocaine withdrawal exhibited a significant attenuation of anxiety-like behavior characterized by increased time spent in the open arms and increased entries into the open arms compared to animals treated with only saline during cocaine withdrawal. Betaxolol hydrochloride did not produce anxiolytic-like effects in control animals treated chronically with saline [1]. Betaxolol hydrochloride produces less systemic beta 2- and possibly beta 1-adrenergic receptor blockade than either timolol or levobunolol. Betaxolol hydrochloride may be relatively safer to use in patients with reactive airway disease than either timolol or levobunolol [2]. has

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

[1]. Rudoy, C.A. and E.J. Van Bockstaele, Betaxolol, a selective beta(1)-adrenergic receptor antagonist, diminishes anxiety-like behavior during early withdrawal from chronic cocaine administration in rats. Prog Neuropsychopharmacol Biol Psychiatry, 2007. 31(5
[2]. Lesar, T.S., Comparison of ophthalmic beta-blocking agents. Clin Pharm, 1987. 6(6): p. 451-63.

In Vitro: DMSO : ≥ 100 mg/mL (290.79 mM)H₂O : 10 mg/mL (29.08 mM; Need ultrasonic)