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Carbazochrome

(Synonyms: 卡巴克络；卡络柳钠)

目录号: PL14259 纯度: ≥99%

Carbazochrome 是一种毛细管稳定剂，用于出血的研究。Carbazochrome 是一种抗出血剂。

CAS No. :69-81-8

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中文名称	Carbazochrome
中文别名	卡巴克络;消旋-1-甲基-羟基-5,6-酮基甲氢吲哚单缩氨脲;安络血;肾上腺色素缩胺脲;3-羟基-1-甲基二氢吲哚-5,6-二酮缩氨脲;肾上腺色素缩氨脲;Carbazochrome 卡巴克络;安络血标准品;安络血(肾上腺色腙);氨基甲酰;卡巴克洛;卡巴克络安络血肾上腺色腙;卡巴克络（安络血）;卡巴克络（肾上腺色腙）;卡络;卡马西平;肾上腺色腙;卡巴克络,肾上腺色素缩胺脲
英文名称	Carbazochrome
英文别名	2-(3-Hydroxy-1-methyl-6-oxo-2,3-dihydro-1H-indol-5(6H)-ylidene)hydrazinecarboxamide;adrenochrome monosemicarbazone;Carbazochrome;Adrenochrome Semicarbazone;3-HYDROXY-1-METHYL-5,6-INDOLINEDIONE SEMICARBAZONE;adchnon;adedolon;Adrenochrom-monosemicarbazon;ADRENOXYL;adrezon;adrokson;adroxon;cartabes;CROMADRENAL;CROMOSIL;3-Hydroxy-1-methyl-5,6-indolinedione 5-semicarbazone;Carbazochrom;Adrenostazin;Sangostasin;Sangostazin;Adrenostan;Carbazochromum;Carbazocromo;Cromoxin;Adenocrome monosemicarbazone;Adrenoxil;Apara;Carbazochrome [INN:JAN];Adrenochrome monosemicarbazon;Carbazocromo [INN-Spanish];Car;Adrenochrome monosemicarbazone; Adrenostazin; Adrenoxyl; Adrezon;SCHEMBL11036230;Adrenochrome semicarbazone;Cartabes;carbazochrome;Adroxon;3-Hydroxy-1-methyl-5,6-inodlindionsemicarbazon;W-104582;DS-4533;CARBAZOCHROME [MI];NCGC00164521-01;SY057431;BCP15360;NSC73742;D01864;NCGC00344541-01;ZINC03871875;{[(5E)-3-Hydroxy-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-indol-5-ylidene]amino}urea;Adedolon;NSC-73742;L 502;CHEMBL2051960;A0176;69-81-8;(3,6-dihydroxy-1-methyl-2,3-dihydroindol-5-yl)iminourea;Cromadrenal;5, 3-hydroxy-1-methyl-, 5-semicarbazone;LS-83455;5,6-INDOLINEDIONE, 3-HYDROXY-1-METHYL-, 5-SEMICARBAZONE;s5084;CS-0013486;CAS-69-81-8;CHEBI:31349;Cromosil;3-Hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione 5-semicarbazone #;(E)-2-(3-hydroxy-1-methyl-6-oxo-2,3-dihydro-1H-indol-5(6H)-ylidene)hydrazinecarboxamide;81F061RQS4;[(Z)-(3-hydroxy-1-methyl-6-oxo-2,3-dihydroindol-5-ylidene)amino]urea;Hydrazinecarboxamide, 2-(1,2,3,6-tetrahydro-3-hydroxy-1-methyl-6-oxo-5H-indol-5-ylidene)-;Adrenochromsemicarbazon;AC-31089;CS-O-01053;CARBAZOCHROME [JAN];Q1104521;XSXCZNVKFKNLPR-SDQBBNPISA-N;CCG-266833;DTXSID3048310;3-Hydroxy-1-methyl-5-semicarbazono-6(5H)-indolinon;ADRENOCHROME MONOSEMICARBAZONE [MI];NSC 73742;Adrokson;2-(1,2,3,6-Tetrahydro-3-hydroxy-1-methyl-6-oxo-5H-indol-5-ylidene)hydrazinecarboxamide;Carbazochromum [INN-Latin];Adrenochrome monosemicarbazone;H11624;CHEMBL4789892;DTXCID00809636;HY-B1587;DB09012;SB67333;AKOS024319075;EINECS 200-717-0;2,3-Dihydro-3-hydroxy-1-methyl-1H-indole-5,6-dione-5-semicarbazone;AKOS015896532;Carbazochrome,(S);CARBAZOCHROME [WHO-DD];5,6-dihydro-3-hydroxy-1-methyl-5,6-indolindion-5-semicarbazon;Adchnon;CARBAZOCHROME [INN];3-Hydroxy-1-methyl-5,6-indolinedione semicarbazone;MFCD00130253;Carbazochrome (JAN/INN);AMY39497;Adrezon;Tox21_113160;Adrenoxyl;Hydrazinecarboxamide,2,3,6-tetrahydro-3-hydroxy-1-methyl-6-oxo-5H-indol-5-ylidene)-;CARBAZOCHROME [MART.];AKOS030242682;UNII-81F061RQS4;SCHEMBL506178
Cas No.	69-81-8
分子式	C₁₀H₁₂N₄O₃
分子量	236.23
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months
详情描述	Carbazochrome 是一种毛细管稳定剂，用于出血的研究。Carbazochrome 是一种抗出血剂。

产品详情	Carbazochrome 是一种毛细管稳定剂，用于出血的研究。Carbazochrome 是一种抗出血剂。
生物活性	Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent.
性状	Solid
体外研究(In Vitro)	Carbazochrome (0.1-10 μM) inhibits the Bradykinin induced and thrombin-induced formation of [H]IP3 in a concentration-dependent manner.Carbazochrome (0.1-1 μM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Toshiaki Sendo, et al. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):175-80. [2]. Toshiaki Sendo, et al. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Eur J Pharmacol. 2002 Aug 23;450(2):203-8.

溶解度数据	In Vitro: H₂O : 5 mg/mL (21.17 mM; ultrasonic and adjust pH to 12 with NaOH)DMSO : 5 mg/mL (21.17 mM; Need ultrasonic)配制储备液

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[1]. Toshiaki Sendo, et al. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):175-80.
[2]. Toshiaki Sendo, et al. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Eur J Pharmacol. 2002 Aug 23;450(2):203-8.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Carbazochrome

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