Ecamsule disodium 一种广谱 UVA 防晒剂，可用于防晒产品。Ecamsule disodium 可减少由太阳辐射引起的生物损害，例如嘧啶二聚体的形成，p53 蛋白的积累或胶原酶 2 的表达。

Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression.

Solid

Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm.
Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment.
. Ecamsule counteractes UV and AAPH induced ROS-formation.
.The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%.
. Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

[1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244.
[2]. Vincent A DeLeo, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103.

In Vitro: H₂O : 50 mg/mL (82.42 mM; ultrasonic and warming and heat to 60°C)DMSO : 50 mg/mL (82.42 mM; Need ultrasonic)配制储备液