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Midaglizole

目录号: PL11683 纯度: ≥98%

Midaglizole ((±)-DG5128 free base, DG5128 free base) 是一种有效的 α2-adrenoceptor 拮抗剂。Midaglizole 是一种降血糖药。Midaglizole 在具有升高血压并降低血糖水平的作用。

CAS No. :66529-17-7

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中文名称	Midaglizole
中文别名	米达里唑;咪格列唑
英文名称	Midaglizole
英文别名	Midaglizole;DG-5;2-(2-phenyl-2-(2-pyridyl))ethyl-2-imidazoline;2-(4,5-Dihydro-1H-imidazol-2-yl)-1-phenyl-1-[2]pyridyl-aethan;2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-1-[2]pyridyl-ethane;2-[2-(2-Imidazolin-2-yl)-1-phenylethyl]pyridine;2-[2-Phenyl-2-(pyridyl)]ethyl-2-imidazolin;4,5-Dihydro-2-[2-(2-pyridinyl)-2-phenylethyl]-1H-imidazole;DG-5128
Cas No.	66529-17-7
分子式	C₁₆H₁₇N₃
分子量	251.33
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Midaglizole ((±)-DG5128 free base, DG5128 free base) 是一种有效的 α2-adrenoceptor 拮抗剂。Midaglizole 是一种降血糖药。Midaglizole 在具有升高血压并降低血糖水平的作用。

产品详情	Midaglizole ((±)-DG5128 free base, DG5128 free base) 是一种有效的 α2-adrenoceptor 拮抗剂。Midaglizole 是一种降血糖药。Midaglizole 在具有升高血压并降低血糖水平的作用。
生物活性	Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo.
性状	Solid
体外研究(In Vitro)	Midaglizole stimulates insulin release with the EC50 values of 200 nM, 24 μM for rat islets and MIN6 β-cell line, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Midaglizole (3, 30 mg/kg; i.v.) increases blood pressure in rats. Midaglizole (0.2, 1, 2 mg/kg; infusion) reduces blood glucose levels in dags. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Hirohashi M, et al. Intrinsic pressor activity of midaglizole, an alpha-2 adrenoceptor antagonist, in pithed rats. Jpn J Pharmacol. 1990 Aug;53(4):519-20. [2]. Ohneda K, et al. Mechanism of insulin secretion by midaglizole. Diabetes Res Clin Pract. 1993 Feb;19(2):127-32. [3]. Proks P, et al. Inhibition of reco

溶解度数据	In Vitro: DMSO : 162.5 mg/mL (646.56 mM; Need ultrasonic)配制储备液

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[1]. Hirohashi M, et al. Intrinsic pressor activity of midaglizole, an alpha-2 adrenoceptor antagonist, in pithed rats. Jpn J Pharmacol. 1990 Aug;53(4):519-20.
[2]. Ohneda K, et al. Mechanism of insulin secretion by midaglizole. Diabetes Res Clin Pract. 1993 Feb;19(2):127-32.
[3]. Proks P, et al. Inhibition of reco

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Midaglizole

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