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YIL781 hydrochloride

目录号: PL11599 纯度: ≥99.0%

YIL781 hydrochloride 是有效的、具有口服活性的胃促生长素受体 (GHSR) 的拮抗剂。YIL781 hydrochloride 可改善大鼠体内葡萄糖稳态。YIL781 hydrochloride 可抑制饥饿素诱导的钙反应，pIC50 值分别为 7.90 和 8.27。

CAS No. :1640226-17-0

商品编号	规格	价格	会员价	是否有货	数量
PL11599-1mg	1mg	询价	询价
PL11599-5mg	5mg	询价	询价

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中文名称	YIL781 hydrochloride
英文名称	YIL781 hydrochloride
英文别名	4(3H)-Quinazolinone, 6-(4-fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-, hydrochloride (1:1);YIL 781;YIL781 (hydrochloride);YIL781;6-(4-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]quinazolin-4-one;hydrochloride;YIL781 hydrochloride;YIL 781 hydrochloride;YIL781 HCl;B7551;6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride
Cas No.	1640226-17-0
分子式	C₂₄H₂₉ClFN₃O₂
分子量	445.96
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	YIL781 hydrochloride 是有效的、具有口服活性的胃促生长素受体 (GHSR) 的拮抗剂。YIL781 hydrochloride 可改善大鼠体内葡萄糖稳态。YIL781 hydrochloride 可抑制饥饿素诱导的钙反应，pIC50 值分别为 7.90 和 8.27。

产品详情	YIL781 hydrochloride 是有效的、具有口服活性的胃促生长素受体 (GHSR) 的拮抗剂。YIL781 hydrochloride 可改善大鼠体内葡萄糖稳态。YIL781 hydrochloride 可抑制饥饿素诱导的钙反应，pIC₅₀ 值分别为 7.90 和 8.27。
生物活性	YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL-781 hydrochloride inhibits the calcium response induced by ghrelin with pIC 50 values of 7.90 and 8.27, respectively.
性状	Solid
体外研究(In Vitro)	YIL-781 (10-300 nM) induces a concentration-dependent parallel rightward shift of the ghrelin CRC with a slight but statistically significant depression of the maximal response at 100 and 300 nM, reaching a similar agonist maximal response of approximately 90%. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	YIL781 (0.1 to 5 μg/5 μl) attenuates ghrelin-induced up-regulation of the blood glucose level. The i.t. treatment with YIL781 alone does not affect the blood glucose level (F = 0.8160; P = 0.5095). has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. William P Esler, et al. Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss Endocrinology. 2007 Nov;148(11):5175-85. [2]. Timothy H. Moran, et al. Gut Peptides: Targets for Antiobesity Drug Development? Endocrinology. 2009 Jun; 150(6): 2526–2530.

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[1]. William P Esler, et al. Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss Endocrinology. 2007 Nov;148(11):5175-85.
[2]. Timothy H. Moran, et al. Gut Peptides: Targets for Antiobesity Drug Development? Endocrinology. 2009 Jun; 150(6): 2526–2530.

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YIL781 hydrochloride

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