S-23
目录号: PL11636 纯度: ≥99%
CAS No. :1010396-29-8
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中文名称
S-23
英文名称
S-23
英文别名
(S)-3-(4-Chloro-3-fluorophenoxy)-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide;S 23;S-23;(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide;(2S)-3-(4-Chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide;S 23 (contraceptive);S-23 99% White powder
Cas No.
1010396-29-8
分子式
C18H13ClF4N2O3
分子量
416.80
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
S-23 是一种口服选择性雄激素受体调节剂 (SARM),Ki 为 1.7 nM。S-23 诱导 CV-1 细胞雄激素受体介导的转录激活。S-23 增加去势大鼠前列腺、精囊和肛提肌重量。
生物活性
S-23 is an orally active selective androgen receptor modulator (SARM) with a K i of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.
性状
Solid
IC50 & Target[1][2]
Ki: 1.7 nM (Androgen receptor)
体外研究(In Vitro)
S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED 50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively. has not independently confirmed the accuracy of these methods. They are for reference only. Animal
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Jones A, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150(1):38
[2]. Thevis M, et al. Characterization of in vitro generated metabolites of the selective androgen receptor modulators S-22 and S-23 and in vivo comparison to post-administration canine urine specimens. Drug Test Anal. 2010;2(11-12):589-598.
溶解度数据
In Vitro: DMSO : 100 mg/mL (239.95 mM; Need ultrasonic)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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