BigLEN(mouse) is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a K d of ~0.5 nM. BigLEN(mouse) can be used to regulate responses associated with food intake and metabolism.
性状
Solid
IC50 & Target[1][2]
Kd: ~0.5 nM (GPR171)
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and lightPowder -80°C 2 years;-20°C 1 year
SequenceShortening
LENPSPQAPARRLLPP
参考文献
[1]. Gomes I, et, al. GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16211-6.[2]. Mack SM, et, al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891.
溶解度数据
In Vitro: H2O : 100 mg/mL (56.95 mM; Need ultrasonic)配制储备液