您当前的位置：

LQZ-7I

目录号: PL11544 纯度: ≥99%

LQZ-7I 是一种靶向 survivin 的抑制剂。LQZ-7I 抑制生存素二聚化。LQZ-7I 口服有效抑制异种移植肿瘤生长并诱导肿瘤中生存素的损失。

CAS No. :195822-23-2

商品编号	规格	价格	会员价
PL11544-5mg	5mg	¥488.00	请登录
PL11544-10mg	10mg	¥823.00	请登录
PL11544-25mg	25mg	¥1655.00	请登录
PL11544-50mg	50mg	¥2655.00	请登录
PL11544-100mg	100mg	¥3925.00	请登录
PL11544-200mg	200mg	询价	询价
PL11544-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1768.00	请登录
PL11544-1 mL x 10 mM (in DMSO)		¥542.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

*注意事项:下单时请联系销售核实产品价格及货期，避免后续产生不便，感谢支持!

加入购物车在线咨询收藏产品大包装询价

中文名称	LQZ-7I
英文名称	LQZ-7I
英文别名	LQZ-7I;N2,N3-bis(4-fluorophenyl)quinoxaline-2,3-diamine;N,N'-bis(4-fluorophenyl)quinoxaline-2,3-diamine;2-N,3-N-bis(4-fluorophenyl)quinoxaline-2,3-diamine;ChemDiv3_003976;HMS1484E16;STL432531;IDI1_021886;D81692;2,3-Quinoxalinediamine, N,N'-bis(4-fluorophenyl)-
Cas No.	195822-23-2
分子式	C₂₀H₁₄F₂N₄
分子量	348.35
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	LQZ-7I 是一种靶向 survivin 的抑制剂。LQZ-7I 抑制生存素二聚化。LQZ-7I 口服有效抑制异种移植肿瘤生长并诱导肿瘤中生存素的损失。

产品详情	LQZ-7I 是一种靶向 survivin 的抑制剂。LQZ-7I 抑制生存素二聚化。LQZ-7I 口服有效抑制异种移植肿瘤生长并诱导肿瘤中生存素的损失。
生物活性	LQZ-7I is a survivin-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.
性状	Solid
IC50 & Target[1][2]	Survivin
体外研究(In Vitro)	LQZ-7I has improved cytotoxicity with IC50s of 3.1 μM against C4-2 cells and 4.8 μM against PC-3 cells compared with the parent compound LQZ-7. LQZ-7I (10 μM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin. has not independently confirmed the accuracy of these methods. They are for reference only.Weste
体内研究(In Vivo)	LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Robert Peery,et al. Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. J Med Chem. 2020 Jun 9.

溶解度数据	In Vitro: DMSO : 125 mg/mL (358.83 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

[1]. Robert Peery,et al. Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. J Med Chem. 2020 Jun 9.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

LQZ-7I

相关产品

The molarity calculator equation

The dilution calculator equation