Syk-IN-4||-陌孚医药/Medlife

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Syk-IN-4

目录号: PL11556 纯度: ≥98%

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产品详情	Syk-IN-4 是一种有效的，具有口服活性的选择性 SYK 抑制剂，IC₅₀ 为 0.31 nM。SYK 已成为自身免疫和血液肿瘤等多个研究领域的潜在靶标。
生物活性	Syk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC 50 of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers.
性状	Solid
IC50 & Target[1][2]	IC50: 0.31 nM (SYK)
体外研究(In Vitro)	Syk-IN-4 is a potent inhibitor of hERG with an IC50 of 3.0 μM. Syk-IN-4 inhibits SUDHL-4 and T cell proliferation with GI50s of 0.24 and 2.6 μM, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Syk-IN-4 exhibits moderate oral bioavailability (60%) following oral administration (1 mg/kg) in male Hans Wistar rats. Syk-IN-4 exhibits high plasma clearance (151 mL/min/kg) combined with large volumes of distribution (1.0 L/kg respectively) following i.v. administration (0.5 mg/kg) in male Hans Wistar rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Neil P Grimster, et al. Optimization of a Series of Potent, Selective and Orally Bioavailable SYK Inhibitors. Bioorg Med Chem Lett. 2020 Jul 24;127433.

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (148.99 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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