HP590||-陌孚医药/Medlife

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HP590

目录号: PL11457 纯度: ≥98%

商品编号	规格	价格	会员价
PL11457-5mg	5mg	¥6107.00	请登录
PL11457-10mg	10mg	¥9643.00	请登录
PL11457-25mg	25mg	¥18483.00	请登录
PL11457-50mg	50mg	询价	询价
PL11457-100mg	100mg	询价	询价

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中文名称	HP590
英文名称	HP590
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	HP590 是一种具有口服活性的、新型和强效的 STAT3 抑制剂 (STAT3 荧光素酶活性: IC₅₀=27.8 nM; ATP 抑制: IC₅₀=24.7 nM)。HP590 对胃癌细胞显示出抗增殖活性并可诱导细胞凋亡。
生物活性	HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC 50 =27.8 nM; ATP inhibition: IC 50 =24.7 nM). HP590 shows anti-proliferative activity to gastric cancer cells and induces apoptosis.
性状	Solid
IC50 & Target[1][2]	IC50: 27.8 nM (STAT3 luciferase activity)
体外研究(In Vitro)	HP590 (0-40 μM; 72 h) shows anti-proliferative activities to MKN45, AGS, and MGC803 cells. HP590 (0-40 nM; 0-24 h) inhibits STAT3 Tyr and Ser phosphorylation in GC cells, blocks the expression of STAT3 downstream genes (c-Myc and cyclin D1) in GC cells, reduces IL-6-mediated STAT3 nuclear translocation in MKN45 cells. HP590 (5-20 nM; 48 h) induces gastric cancer cell apoptosis. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	HP590 (oral administration; 25 and 50 mg/kg; once daily; 5 w) inhibits GC growth effectively by inhibiting the STAT3 activation and shows better tolerance in GC xenograft model. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. He P, et al. Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr705/Ser727 Inhibitory Activity for Gastric Cancer Treatment. J Med Chem. 2022 Sep 14.

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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