HJC0152 hydrochloride|1420290-99-8|-陌孚医药/Medlife

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HJC0152 hydrochloride

目录号: PL11478 纯度: ≥98%

CAS No. :1420290-99-8

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PL11478-200mg	200mg	询价	询价
PL11478-500mg	500mg	询价	询价

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中文名称	HJC0152 hydrochloride
中文别名	2-(2-氨基乙氧基)-5-氯-N-(2-氯-4-硝基苯基)苯甲酰胺盐酸盐;STAT3抑制剂(HJC0152 HYDROCHLORIDE);化合物HJC0152 HYDROCHLORIDE
英文名称	HJC0152 hydrochloride
英文别名	HJC0152 hydrochloride;2-(2-Aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide HCl;HJC0152;2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4- nitrophenyl)benzamide hydrochloride;Benzamide, 2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)-, hydrochloride (1:1);HJC0152 HCl;Inhibitor,Apoptosis,HJC 0152,HJC0152 hydrochloride,inhibit,STAT,HJC-0152,HJC-0152 hydrochloride
Cas No.	1420290-99-8
分子式	C₁₅H₁₄Cl₃N₃O₄
分子量	406.65
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	HJC0152 hydrochloride 是信号转导和转录激活因子 3 (STAT3) 的抑制剂。
生物活性	HJC0152 hydrochloride is a signal transducers and activators of transcription 3 (STAT3) inhibitor.
性状	Solid
IC50 & Target[1][2]	STAT3
体外研究(In Vitro)	HJC0152 hydrochloride (compound 11) significantly inhibits cell proliferation and induces apoptosis accompanying cellular morphological changes at concentrations of 1, 5, and 10 μM. Results show that treatment with 10 μM HJC0152 hydrochloride decreases the STAT3 promoter activity in MDA-MB-231 cells by approximately 32%, and increasing the dose of HJC0152 hydrochloride to 20 μM further decreases STAT3 promoter activity by 62% as compare with control. Total STAT3 is reduced after treatment with HJC0152 hydrochloride. HJC0152 hydrochloride induces cleaved caspase-3 and down regulates cyclin D1 in MDA-MB-231 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Mice treated with 7.5 mg/kg of HJC0152 hydrochloride (compound 11) via ip show a better effect in inhibiting tumor growth. The growth of xenograft tumors in mice is significantly reduced by HJC0152 hydrochloride at a dose of 25 mg/kg. It is also noteworthy that HJC0152 hydrochloride does not show significant signs of toxicity at a dose of 75 mg/kg. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Chen H, et al. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. ACS Med Chem Lett. 2013 Feb 14;4(2):180-185.

溶解度数据	In Vitro: DMSO : 1 mg/mL (2.46 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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