MSC2360844 hemifumarate|1621688-31-0|(MSC2360844 hemifumarate; IOA-244 hemifumarate)-陌孚医药/Medlife

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MSC2360844 hemifumarate (Synonyms: MSC2360844 hemifumarate; IOA-244 hemifumarate)

目录号: PL09771 纯度: ≥99%

CAS No. :1621688-31-0

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中文名称	MSC2360844 hemifumarate
英文名称	MSC2360844 hemifumarate
英文别名	MSC2360844 hemifumarate;Roginolisib hemifumarate
Cas No.	1621688-31-0
分子式	C₁₁H₁₈FN₂O₁₄P₃
分子量	514.19
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	MSC2360844 hemifumarate 是一种有效的，具有口服活性的选择性 PI3Kδ 抑制剂，IC₅₀为 145 nM。MSC2360844 hemifumarate 对一组 278 种其他激酶显示出高度选择性。
生物活性	MSC2360844 hemifumarate is a potent, orally active and selective PI3Kδ inhibitor, with an IC 50 of 145 nM. MSC2360844 hemifumarate shows highly selective against a panel of 278 additional kinases.
性状	Solid
IC50 & Target[1][2]	PI3Kδ 145 nM (IC50)
体外研究(In Vitro)	MSC2360844 hemifumarate (0-10 μM; 1 hours) completely abolished BCR-induced pAkt in Ramos B cells in a concentration-dependent manner with IC50 values of 280?nM. MSC2360844 hemifumarate inhibits B cell proliferation in a concentration-dependent manner with an IC50 of 48?nM. MSC2360844 hemifumarate blocks BCR- and TCR-mediated responses in lymphocytes and TLR-induced IFNα by pDC in human primary cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	MSC2360844 hemifumarate (6.6-66 mg/kg; daily from week 2 to 10) ameliorates disease manifestations in a murine SLE model. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: NZB/W F1 fema
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Haselmayer P, et al. Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies. Front Immunol. 2014 May 22;5:233.

溶解度数据	In Vitro: DMSO : 100 mg/mL (171.05 mM; Need ultrasonic)配制储备液

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