Flupentixol dihydrochloride|2413-38-9|(Flupenthixol dihydrochloride)-陌孚医药/Medlife

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Flupentixol dihydrochloride (Synonyms: Flupenthixol dihydrochloride)

目录号: PL09822 纯度: ≥99%

CAS No. :2413-38-9

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中文名称	Flupentixol dihydrochloride
中文别名	盐酸氟哌噻吨;(Z)-4-[3-[2-(三氟甲基)-9H-硫杂蒽-9-亚基]丙基]-1-哌嗪基乙醇二盐酸盐;盐酸氟哌噻吨 GMP资质齐全;Flupentixoldihydrochloride（顺+反）;氟哌噻吨盐酸盐 EP标准品;盐酸氟哌噻吨标准品
英文名称	Flupentixol dihydrochloride
英文别名	Fupentixol dihydrochloride;4-[3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]piperazine-1-ethanol dihydrochloride;(Z)-4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]piperazine-1-ethanol dihydrochloride;Flupenthixol dihydrochloride;Flupenthixol dihydrochloride,4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanoldihydrochloride;4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride;Fluanxol dihydrochloride;FLUPENTIXOL DIHYDROCHLORIDE;flupentixolhydrochloride;Fupentixol HCl;fx703;Zimelidine dihydrochloride;Flupentixol dihydrochloride
Cas No.	2413-38-9
分子式	C₂₃H₂₅F₃N₂Os^.₂(HCl)
分子量	507.44
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

Flupentixol dihydrochloride 是一种具有口服活性的 D₁/D₂ 多巴胺受体拮抗剂和新型 PI3K 抑制剂 (PI3Kα IC₅₀=127 nM)。Flupentixol dihydrochloride 具有对癌细胞的抗增殖活性并诱导细胞凋亡。Flupentixol dihydrochloride 也可用于精神分裂症、焦虑和抑郁症的研究。

生物活性

Flupentixol is an orally active D 1 /D 2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC 50 =127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research.

性状

Solid

IC50 & Target[1][2]

PI3Kα 127 nM (IC50) D1 Receptor pan>&nb

体外研究(In Vitro)

Flupentixol (2.5-40 μM; 72 h) treatment inhibits the viability of lung cancer cells in a dose-dependent manner.
Flupentixol (2.5-40 μM; 24 h) induces apoptosis in lung cancer cells.
Flupentixol (2.5-15 μM; 24 h) inhibits p-AKT and Bcl-2 expression levels. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay

体内研究(In Vivo)

Flupentixol (intragastric injection; 40 mg/kg; once daily; 21 d) suppresses A549 xenografted tumor growth in nude mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: BALB/C nude mic

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Yonar D, et al. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun;198:61-71.
[2]. Ruhrmann S, et al. Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1012-22.

溶解度数据	In Vitro: H₂O : 100 mg/mL (197.07 mM; Need ultrasonic)DMSO : 33.33 mg/mL (65.68 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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