Nomegestrol acetate|58652-20-3|(醋酸诺美孕酮)-陌孚医药/Medlife

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Nomegestrol acetate (Synonyms: 醋酸诺美孕酮)

目录号: PL10077 纯度: ≥99%

CAS No. :58652-20-3

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中文名称	Nomegestrol acetate
中文别名	诺美孕酮醋酸酯;醋酸诺美孕酮;醋酸诺美
英文名称	Nomegestrol acetate
英文别名	Nomegestrone Acetate;17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione 17-acetate;Nomegestrol 17-acetate;Nomegestrol 17-acetate;Nomegestrol Acetate;[(8S,9S,10R,13S,14S,17R)-17-acetyl-6,13-dimethyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate;Nomegestrol acetate
Cas No.	58652-20-3
分子式	C₂₃H₃₀O₄
分子量	370.49
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Nomegestrol acetate 是一种口服有效的高选择性孕激素，也是孕酮受体 (progesterone receptor) 完全激动剂，能抑制排卵。Nomegestrol acetate 还能有效抑制人类子宫内膜癌 RL95-2 细胞体外和体内增殖。Nomegestrol acetate 可用于癌症 (尤其是子宫内膜癌) 和避孕的研究。

生物活性

Nomegestrol acetate is an orally active, highly selective progestogen and a progesterone receptor complete agonist. Nomegestrol acetate inhibits ovulation. Nomegestrol acetate is also effective in inhibiting the proliferation of human endometrial cancer RL95-2 cells in vitro and in vivo. Nomegestrol acetate can be used in cancer (especially endometrial cancer) and contraceptive studies.

性状

Solid

IC50 & Target[1][2]

Progesterone receptor.

体外研究(In Vitro)

Nomegestrol acetate (0.3, 1, 3, 10, 30, 100 μM; 24, 48, 72 h) shows anti-proliferative activity against RL95-2 cells in a dose-dependent manner.
Nomegestrol acetate (4, 20, 100 μM; 6, 24, 48 h) upregulates protein levels of SUFU and Wnt7a in RL95-2 cells. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation Assay

体内研究(In Vivo)

Nomegestrol acetate (50, 100, 200 mg/kg; p.o.; single daily for 28 days) inhibits growth of RL95-2 xenograft tumors in vivo.
Nomegestrol acetate (100, 200 mg/kg; p.o.; single daily for 28 days) surpresses the expression of SUFU and Wnt7a in tumor tissues.
Nomegestrol acetate (1, 2.5 mg/rat; p.o.; single daily for 4 days) inhibits ovulation in rats. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Ma AY, et al. Nomegestrol Acetate Suppresses Human Endometrial Cancer RL95-2 Cells Proliferation In Vitro and In Vivo Possibly Related to Upregulating Expression of SUFU and Wnt7a. Int J Mol Sci. 2017 Jun 22;18(7):1337.
[2]. van Diepen HA, et al. Nomegestrol acetate: steroid receptor transactivation profile in Chinese hamster ovary cells and ovulation inhibition in rat and monkey. Contraception. 2011 Aug;84(2):199-204.

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (168.70 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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