α-Synuclein (61-75) TFA 是 α-Synuclein 的 61-75 片段。α-Synuclein 是一种丰富的神经元蛋白，在突触前神经末梢高度丰富。α-Synuclein 是一种帕金森氏病 (PD) 的生物标志物。

α-Synuclein (61-75) TFA is the 61-75 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. α-Synuclein is a potential biomarker for Parkinsons disease (PD).

Solid

Lewy bodies containing α-synuclein are a neuropathological hallmark of PD, and missense mutations in α-Synuclein (A30P, E46K, H50Q, G51D, A53E, A53T), as well as α-Synuclein gene duplications and triplications, appear to cause PD. Moreover, polymorphisms in regulatory elements of the α-Synuclein gene predispose individuals to PD and are linked to an early onset of the disease. The non-Aβ-amyloid component (NAC) region of α-synuclein is relatively hydrophobic and aggregation-prone in human α-Synuclein but not in mouse α-Synuclein nor in the corresponding homologous region of human β-synuclein. Yet, β-synuclein is more homologous to α-Synuclein in the N-terminal sequences (74%) than γ-synuclein (67%). has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

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[1]. Jacqueline Burré, et al. Cell Biology and Pathophysiology of α-Synuclein. Cold Spring Harb Perspect Med. 2018 Mar 1;8(3):a024091.
[2]. Nelson Ferreira, et al. Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain. Acta Neuropathol Commun. 2021 Feb 25;9(1):31.

In Vitro: DMSO : 100 mg/mL (64.74 mM; Need ultrasonic)配制储备液