您当前的位置：

Quetiapine

(Synonyms: 喹硫平; ICI204636)

目录号: PL09255 纯度: ≥99%

Quetiapine (ICI204636) 是一种 5-HT 受体激动剂，对人 5-HT1A 的 pEC50 值为 4.77。Quetiapine 是多巴胺受体 (dopamine receptor) 拮抗剂，对人 D2 的 pIC50 值为 6.33。Quetiapine 对人 D2，HT1A，5-HT2A，5-HT2C 受体具有中高等亲和力，pKi 值为 7.25，5.74，7.54，5.55。具有抗抑郁和抗焦虑作用。

CAS No. :111974-69-7

商品编号	规格	价格	会员价
PL09255-10mg	10mg	¥884.00	请登录
PL09255-50mg	50mg	¥1591.00	请登录
PL09255-100mg	100mg	¥1928.00	请登录
PL09255-200mg	200mg	询价	询价
PL09255-500mg	500mg	询价	询价
PL09255-10mM*1mLinDMSO	10mM*1mLinDMSO	¥980.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Quetiapine
中文别名	喹硫平;11-[4-[2-(2-羟基乙氧基)乙基]-1-哌嗪基]二苯并[b,f][1,4]硫氮杂卓;庚酸乙酯;喹硫平富马酸盐;喹硫平杂质;富马酸喹硫平D4
英文名称	Quetiapine
英文别名	QUETIAPINE-D4 FUMARATE;QUETIAPIN;2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol;Quetiapine;11-[4-[2-(2-Hydroxyethoxy)ethyl]piperazino]dibenzo[b,f][1,4]thiazepine;2-[2-[4-[Dibenzo[b,f][1,4]thiazepin-11-yl]piperazin-1-yl]ethoxy]ethanol;2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethanol;2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol;[14C]-Quetiapine;11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine;2-(2-(4-dibenzo[b,f][1,4]thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol;Co-Quetiapine;quetiapina;Quetiapine [INN:BAN];quetiapinum;Seroquel;UNII-BGL0JSY5SI;uetiapine;Ketipinor;Dibenzo[b,f][1,4]thiazepine, ethanol deriv.;2-[2-(4-benzo[b][1,5]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol
Cas No.	111974-69-7
分子式	C₂₁H₂₅N₃O₂S
分子量	383.51
包装储存	Pure form -20°C 3 years；4°C 2 years

产品详情

Quetiapine (ICI204636) 是一种 5-HT 受体激动剂，对人 5-HT1A 的 pEC₅₀ 值为 4.77。Quetiapine 是多巴胺受体 (dopamine receptor) 拮抗剂，对人 D2 的 pIC₅₀ 值为 6.33。Quetiapine 对人 D2，HT1A，5-HT2A，5-HT2C 受体具有中高等亲和力，pK_i 值为 7.25，5.74，7.54，5.55。具有抗抑郁和抗焦虑作用。

生物活性

Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC 50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC 50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK i s of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.

性状

Oil

IC50 & Target[1][2]

5-HT1A Receptor 5.74 (pKi) 5-HT2A Receptor

体外研究(In Vitro)

Quetiapine (<100?μM; 24?hours) has no significant effect on cell viabilities.
Quetiapine (10?μM) inhibits NO release, which increased by LPS (0.1-100 ng/mL) in concentration-dependent manner.
Quetiapine (10?μM) also inhibits TNF-α synthesis.
has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay

体内研究(In Vivo)

Quetiapine (10?mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ)-induced chronic mouse model of demyelination. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.
[2]. Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492.

溶解度数据	In Vitro: Ethanol : 100 mg/mL (260.75 mM; Need ultrasonic)DMSO : 100 mg/mL (260.75 mM; Need ultrasonic)H₂O : 0.1 mg/mL (0.26 mM; ultrasonic and warming and heat to 50°C)

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Quetiapine

相关产品

The molarity calculator equation

The dilution calculator equation