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Apraclonidine hydrochloride

(Synonyms: ALO 2145)

目录号: PL09191 纯度: ≥98%

Apraclonidine hydrochloride (ALO 2145) 是一种选择性 α2 和弱 α1 受体激动剂，能有效降低人眼压。Apraclonidine hydrochloride 是一种局部滴眼液，有提升眼睑的能力。

CAS No. :73218-79-8

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中文名称	Apraclonidine hydrochloride
中文别名	盐酸安普乐定;盐酸阿可乐定;2-(4-氨基-2,6-二氯苯胺基)-2-咪唑啉盐酸盐;盐酸阿可乐定（曾用名：盐酸安普乐定）;安普乐定;盐酸阿可乐定 USP标准品;盐酸安普乐定(盐酸阿可乐定);盐酸阿可乐定,2-(4-氨基-2,6-二氯苯胺基)-2-咪唑啉盐酸盐
英文名称	Apraclonidine hydrochloride
英文别名	2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride;2-(4-Amino-2,6-dichloroanilino)-2-imidazoline hydrochloride;Apraclonidine Hydrochloride;2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine,hydrochloride;APRACLONIDINE HCL;2-(4-Amino-2,6-dichlorophenylimino)imidazolidine;2-[(2,6-dichloro-4-aminophenyl)imino]imidazolidine hyd;2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine monohydrochloride;ALO-2145;Iopidine ophthalmic solution;mono hydrochloride;NC 14 hydrochloride;p-aminoclonidine;p-aminoclonidine hydrochloride;UNII-D2VW67N38H;p-Aminoclonidine monohydrochloride;Iopidine;3,5-Dichloro-4-(2-imidazolidinylidenimino)aniline hydrochloride;2-(4-Amino-2,6-dichlorophenylimino)imidazolidine hydrochloride;Apraclonidine hydrochloride;2-((4-Amino-2,6-dichlorophenyl)imino)imidazolidine monohydrochloride;D2VW67N38H;NC;Apraclonidine hydrochloride
Cas No.	73218-79-8
分子式	C₉H₁₁Cl₃N₄
分子量	281.57
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Apraclonidine hydrochloride (ALO 2145) 是一种选择性 α2 和弱 α1 受体激动剂，能有效降低人眼压。Apraclonidine hydrochloride 是一种局部滴眼液，有提升眼睑的能力。

产品详情

Apraclonidine hydrochloride (ALO 2145) 是一种选择性 α2 和弱 α1 受体激动剂，能有效降低人眼压。Apraclonidine hydrochloride 是一种局部滴眼液，有提升眼睑的能力。

生物活性

Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid.

性状

Solid

体外研究(In Vitro)

Apraclonidine hydrochloride (ALO 2145) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Apraclonidine hydrochloride (ALO 2145) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery
. Apraclonidine (1.15%, single instillation) inhibits 98% of PGE2-induced aqueous flare elevationy
. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Wijemanne S, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci. 2017;376:129‐132.
[2]. Searles RV, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999;58(4):220‐226.
[3]. Yoriko Hayasaka, et al. Effects of topical antiglaucoma eye drops on p

溶解度数据	In Vitro: DMSO : 125 mg/mL (443.94 mM; Need ultrasonic)H₂O : ≥ 12.5 mg/mL (44.39 mM)

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Apraclonidine hydrochloride

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