TPP-1|2426685-25-6|-陌孚医药/Medlife

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TPP-1

目录号: PL08959 纯度: ≥98%

CAS No. :2426685-25-6

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中文名称	TPP-1
英文名称	TPP-1
英文别名	TPP-1
Cas No.	2426685-25-6
分子式	C₁₀₇H₁₅₀N₃₄O₃₂S₂
分子量	2488.68
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	TPP-1 是 PD-1/PD-L1 相互作用的有效抑制剂。TPP-1 与 PD-L1 特异性高亲和力结合 (K_D=95 nM)。动物模型中，TPP-1 通过再激活 T 细胞功能抑制肿瘤生长。
生物活性	TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (K D =95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function.
性状	Solid
体外研究(In Vitro)	TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The KD value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1. TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	SGQYASYHCWCWRDPGRSGGSK
参考文献	[1]. Chunlin Li, et al. Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy. Cancer Immunol Res. 2018 Feb;6(2):178-188.

溶解度数据	In Vitro: H₂O : 50 mg/mL (20.09 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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