Pembrolizumab|1374853-91-4|(帕博利珠单抗; MK-3475; Lambrolizumab)-陌孚医药/Medlife

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Pembrolizumab (Synonyms: 帕博利珠单抗; MK-3475; Lambrolizumab)

目录号: PL08969 纯度: ≥98%

CAS No. :1374853-91-4

商品编号	规格	价格	会员价
PL08969-1mg	1mg	¥4661.00	请登录
PL08969-5mg	5mg	¥9482.00	请登录
PL08969-25mg	25mg	¥34797.00	请登录
PL08969-50mg	50mg	¥56254.00	请登录
PL08969-100mg	100mg	询价	询价
PL08969-200mg	200mg	询价	询价

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中文名称	Pembrolizumab
中文别名	派姆单抗;帕博利珠单抗
英文名称	Pembrolizumab
英文别名	Pembrolizumab;Keytruda;Lambrolizumab;Lanbrolizumab;MK 3475;Merck 3475
Cas No.	1374853-91-4
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Pembrolizumab (MK-3475) 是一种人源化 IgG4 抗体，为 PD-1 的抑制剂，用于癌症免疫的研究。

生物活性

Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.

性状

Liquid

IC50 & Target[1][2]

IC50: 0.6 nM (PD-1)

体外研究(In Vitro)

Pembrolizumab (MK-3475) increases the secretion of cytokines IFN-γ, TNF-α and the apoptotic cell death of A549 cells.
Pembrolizumab improves the αROR1-CAR T-mediated cytotoxicity, and reduces tumorigenesis in the co-cultured αROR1-CAR T and A549 cells by blocking PD-1::PD-L1 interaction in αROR1-CAR T cells.
has not independently confirmed the accuracy of these methods. They are for reference only.Cell Cytotoxicity Assay

体内研究(In Vivo)

Pembrolizumab inhibits tumor size in A549 xenograft mice pretreated by pressure. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Six-week-old male BALB/c athymic nude mice

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Schachter J, et al. Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006). Lancet. 2017 Aug 16. pii: S0140-6736(17)31601-X.
[2]. Zhenglin Ou, et al. Pressure increases PD?L1 expression in A549 lung adenocarcinoma cells and causes resistance to anti?ROR1 CAR T cell?mediated cytotoxicity, Sci Rep

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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