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Benfluorex hydrochloride

目录号: PL08648 纯度: ≥99%

Benfluorex hydrochloride (JP-992 hydrochloride) 是一个肝核因子 4α (HNF4α) 激活剂。

CAS No. :23642-66-2

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中文名称	Benfluorex hydrochloride
中文别名	盐酸苯氟雷司;盐酸苯氟雷司标准品;N-(1-甲基-2-(3-[三氟甲基]-苯基)乙基]氨基乙醇苯甲酸酯
英文名称	Benfluorex hydrochloride
英文别名	2-((1-(3-(Trifluoromethyl)phenyl)propan-2-yl)amino)ethyl benzoate hydrochloride;BenfluorexHydrochloride;Benfluorex (hydrochloride);Ethanol,2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]-, 1-benzoate,hydrochloride (1:1);2-((1-Methyl-2-(3-(trifluoromethyl)phenyl)ethyl)amino)ethyl benzoate hydrochloride;2-((alpha-Methyl-m-(trifluoromethyl)phenethyl)amino)ethanol benzoate (ester);2-({1-[3-(Trifluoromethyl)phenyl]prop-2-yl}amino)ethyl benzoate hydrochloride;2-(alpha-Methyl-3-(trifluoromethyl)phenylethylamino)ethyl benzoat;2-(-Methyl-3-(trifluoromethyl)phenethylamino)ethyl benzoate hydrochloride;Balans;Benfluorex HCl;Ethanol, 2-((1-methyl-2-(3-(trifluoromethyl)phenyl)ethy;JP 992;Lipophoral;Mediator;Mediaxal;UNII-X7O165XZ00;2-[[1-Methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]ethanol benzoate hydrochloride;Benfluorex hydrochloride;JP-992 hydrochloride
Cas No.	23642-66-2
分子式	C₁₉H₂₀NO₂F₃^.HCl
分子量	387.82
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Benfluorex hydrochloride (JP-992 hydrochloride) 是一个肝核因子 4α (HNF4α) 激活剂。

产品详情

Benfluorex hydrochloride (JP-992 hydrochloride) 是一个肝核因子 4α (HNF4α) 激活剂。

生物活性

Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.

性状

Solid

IC50 & Target[1][2]

HNF4α

体外研究(In Vitro)

Benfluorex hydrochloride consistently activates insulin promoter activity as measured by an increased number of GFP-positive cells. Benfluorex hydrochloride increases the number of GFP-positive cells in a dose-responsive manner and increases the level of endogenous insulin mRNA. Consistent with being HNF4α activator, Benfluorex hydrochloride stimulates HNF4α expression. Benfluorex hydrochloride alters HNF4α protease sensitivity, while the inactive control compound does not. Benfluorex hydrochloride decreases, in a concentration-dependent manner, the synthesis of acid-soluble products and ketone bodies from oleate, whereas the production of CO2 into citric acid cycle is markedly increased by Benfluorex hydrochloride. Benfluorex hydrochloride inhibits in a dose-dependent manner the rates of gluconeogenesis from lactate/pyruvate (10/1 nM).

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Lee SH, et al. Identification of alverine and benfluorex as HNF4α activators. ACS Chem Biol. 2013 Aug 16;8(8):1730-6.
[2]. Kohl C, et al. Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression. Diabetes. 2002 Aug;51(8):2363-8.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (257.85 mM)H₂O : 2.27 mg/mL (5.85 mM; ultrasonic and warming and heat to 60°C)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Benfluorex hydrochloride

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