AP39 是三苯基膦衍生的茴香脑二硫代硫酮和靶向线粒体的硫化氢 (H₂S) 供体。AP39 在氧化应激条件下发挥细胞保护作用并保持线粒体 DNA 完整性。AP39 增加细胞内 H₂S 水平。AP39 可以防止小鼠模型中心肌再灌注损伤，有潜力用于阿尔茨海默氏病的研究。

AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H 2 S) donor. AP39 increases intracellular H 2 S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury in mice model and has the potential for Alzheimers disease research.

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AP39 (25,100?nM; for 24?h) results in increase in cell viability in APP/PS1 neurons and has no effect on cell viability in WT neurons.
AP39 (100?nM) increases the levels of OPA1 and Mfn1 but not Mfn2. Moreover, AP39 decreases the levels of Fis1 but not Drp1.
AP39 (25-250?nM; 2 h) induces a concentration-dependent increase in H2S generation and in the fluorescence of the H2S-detecting dye AzMC.
AP39 (100?nM) significantly increases the basal respiratory rate and the OCR-linked maximal respiratory capacity of the APP/PS1 neurons. AP39 significantly increases the ATP production in WT and APP/PS1 neurons. AP39 significantly protects against mtDNA damage in APP/PS1 neurons by partially restoring mtDNA integrity.
AP39 consists of a mitochondria-targeting motif, triphenylphosphonium (TPP), coupled to a H2S-donating moiety (dithiole

AP39 (100?nM/kg/day; ip; for 6 weeks) ameliorates the learning and memory deficits of APP/PS1 mice. AP39 (25-250?nM/kg/day; ip; for 6 weeks) induces a dose-dependent increase in H 2 S generation in the cortex and hippocampus of WT and APP/PS1 mice.
AP39 (0.01, 0.1, 1 μmol/kg; iv; bolus 10 min before reperfusion) dose‐dependently reduces infarct size anaesthetized by thiobutabarbital (200 mg/kg, i.p) in male Sprague Dawley rats, 300-350 g (9-11 weeks).
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

[1]. Feng-Li Zhao, et al. AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimers Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons. Oxid Med Cell Longev. 2016;2016:8360738.
[2]. Bartosz Szczesny, et al. AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in

In Vitro: DMSO : 100 mg/mL (138.55 mM; Need ultrasonic)配制储备液