Dexamethasone palmitate

目录号: PL08638 纯度: ≥98.0%
Dexamethasone palmitate (DXP) 是 Dexamethasone (HY-14648) 的前体药物。Dexamethasone palmitate 可用于炎症的研究。
CAS No. :14899-36-6
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中文名称
Dexamethasone palmitate
中文别名
地塞米松棕榈酸酯;1,3-金刚烷二羧酸二甲酯
英文名称
Dexamethasone palmitate
英文别名
Dexamethasone palmitate;9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 21-palmitate;DEXAMETHASOME PALMITATE;Dexamethasone 21-Palmitate;Dexamethasone palmitate (jan);Dexamethasone-21-palmitate;dexapalmitate;DXM-21-palmitate;Limethason;Limethason (tn);Limethasone;Lipotalon;D01615
Cas No.
14899-36-6
分子式
C38H59O6F
分子量
630.87
包装储存
Powder -20°C 3 years;4°C 2 years
详情描述
Dexamethasone palmitate (DXP) 是 Dexamethasone (HY-14648) 的前体药物。Dexamethasone palmitate 可用于炎症的研究。
产品详情
Dexamethasone palmitate (DXP) 是 Dexamethasone (HY-14648) 的前体药物。Dexamethasone palmitate 可用于炎症的研究。
生物活性
Dexamethasone palmitate (DXP) is a prodrug of Dexamethasone (HY-14648). Dexamethasone palmitate can be used for the research of inflammation.
性状
Solid
体外研究(In Vitro)
Dexamethasone palmitate (100 μg/mL; 48 h) affects cytokines concentration of RAW 264.7 cells. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability AssayCell Line
体内研究(In Vivo)
Dexamethasone palmitate (1280 μg; IVT injection once) shows different distribution in ocular tissue at different times.
Dexamethasone palmitate (280-1280 μg; IVT injection once) affects VEGF-induced vascular hyperpermeability. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Lorscheider M, et al. Dexamethasone palmitate nanoparticles: An efficient treatment for rheumatoid arthritis. J Control Release. 2019 Feb 28;296:179-189.
[2]. Daull P, et al. A preliminary evaluation of dexamethasone palmitate emulsion: a novel intravitreal sustained delivery of corticosteroid for treatment of macular edema. J Ocul Pharmacol Ther. 2013 Mar;29(2):258-69.
溶解度数据
In Vitro: DMSO : 50 mg/mL (79.26 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)
[1]. Lorscheider M, et al. Dexamethasone palmitate nanoparticles: An efficient treatment for rheumatoid arthritis. J Control Release. 2019 Feb 28;296:179-189.
[2]. Daull P, et al. A preliminary evaluation of dexamethasone palmitate emulsion: a novel intravitreal sustained delivery of corticosteroid for treatment of macular edema. J Ocul Pharmacol Ther. 2013 Mar;29(2):258-69.

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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