TH5487|2304947-71-3|-陌孚医药/Medlife

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TH5487

目录号: PL08627 纯度: ≥99%

CAS No. :2304947-71-3

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中文名称	TH5487
英文名称	TH5487
英文别名	TH5487;4-(4-bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide;GTPL10184;4-(4-Bromo-2-oxo-3H-benzimidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide;TH 5487;4-(4-Bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide;4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide;K8Q;BCP33761;s8913;BT168024;TH 5487; TH 5487
Cas No.	2304947-71-3
分子式	C₁₉H₁₈BrIn₄O₂
分子量	541.18
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	TH5487 是一种有效的 8-氧鸟嘌呤 DNA 糖基化酶1 (OGG1) 抑制剂，IC₅₀ 为342 nM，TH5487 阻止 OGG1 识别其 DNA 底物，抑制 DNA 修复和修饰 OGG1 染色质动力学，从而抑制促炎基因。
生物活性	TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC 50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes.
性状	Solid
体外研究(In Vitro)	TH5487 (5 μM; 1 hour) decreases TNFα- and LPS-induced proinflammatory gene expression to near pretreatment levels. TH5487 (0-10 μM; 1 hour) perturbs binding of NF-κB to 8-oxoG–containing synthetic DNA in nuclear extracts from MLE 12 or hSAEC cells. has not independently confirmed the accuracy of these methods. They are for reference only.RT-PCR
体内研究(In Vivo)	TH5487 (prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours) decreases TNFα or LPS induced the robust recruitment of neutrophils to the airways, and reduces the pulmonary neutrophil count in a time-dependent manner. has not independently confirmed the accuracy of these methods. They are for reference only. Ani
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Visnes T, et al. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science. 2018 Nov 16;362(6416):834-839.

溶解度数据	In Vitro: DMSO : 25 mg/mL (46.20 mM; Need ultrasonic)配制储备液

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