Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
产品详情
QL9 是针对2C T细胞受体 (TCR) 的高亲和力同种异体抗原。
生物活性
QL9 (QLSPFPFDL) is a high-affinity alloantigen for the 2C T cell receptor (TCR).
性状
Solid
IC50 & Target[1][2]
TCR
体外研究(In Vitro)
Mouse T cell clone 2C recognizes two different major histocompatibility (MHC) ligands, the self MHC K and the allogeneic MHC L. Two distinct peptides, SIY (SIYRYYGL) and QL9 (QLSPFPFDL), act as strong and specific agonists when bind to K and L, respectively. QL9 binding to MHC L is influenced by the majority of peptide side chains, distributed across the entire length of the peptide. Findings with both systems, but QL9-L in particular, suggest that many single-residue substitutions, introduced into peptides to improve their binding to MHC and thus their vaccine potential, could impair T cell reactivity due to their dual impact on TCR binding. T cell activation assays are performed to measure effects of peptide SIY and QL9 residues on T cell function. has not independently confirmed the accuracy of these methods. They ar
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
SequenceShortening
QLSPFPFDL
Sequence
Gln-Leu-Ser-Pro-Phe-Pro-Phe-Asp-Leu
参考文献
[1]. Speir JA, et al. Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes. Immunity. 1998 May;8(5):553-62.[2]. Bowerman NA, et al. Different strategies adopted by K(b) and L(d) to generate T cell specificity directed against their respective bound peptides. J Biol Chem. 2009 Nov 20;284(47):32551-61.
溶解度数据
In Vitro: H2O : 33.33 mg/mL (31.35 mM; Need ultrasonic)配制储备液