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Salcaprozate sodium

目录号: PL08580 纯度: ≥99%

Salcaprozate sodium (SNAC) 是一种口服吸收促进剂，有潜力作为口服形式的肝素和胰岛素的递送剂。Salcaprozate sodium 可增加非共价大分子络合引起的亲脂性，从而增加小肠上皮细胞的被动跨细胞渗透。

CAS No. :203787-91-1

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中文名称	Salcaprozate sodium
中文别名	8-(2-羟基苯甲酰胺基)辛酸钠;8-(N-水杨酰基氨基)辛酸单钠;E414单钠盐;N-(水杨酰基)-8-氨基辛酸单钠盐;N-{8-(2苯氧基苯甲酰基)氨基}辛酸单钠;N-水杨酰基-8-氨基辛酸钠;N-[8-( 2-羟基苯甲酰基) 氨基] 辛酸钠;SNAC(索马鲁肽关键辅料)
英文名称	Salcaprozate sodium
英文别名	sodium 8-[(2-hydroxybenzoyl)amino]octanoate;Salcaprozate Sodium;Sodium 8-(2-hydroxybenzamido)octanoate;E414;SNAC;Sodium 8-(salicyloylamino)octanoate;Sodium 8-[(2-hydroxybenzoyl)amino]caprylate;Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate;sodium,8-[(2-hydroxybenzoyl)amino]octanoate;Salcaprozate sodium [USAN];1YTW0422YU;Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, monosodium salt;AK201440;Sodium 8-((2-hydroxybenzoyl)amino)octanoate;Salcaprozate sodium (USAN);Octanoic acid, 8-((2-hydroxybenzoyl)amino)-, monosodium salt;Sodium salcaprozate;Salcaprozic acid, sodium salt;E 414;Salcaprozic acid so;8-(2-hydroxybenzamido)octanoate;Salcaprozate sodium
Cas No.	203787-91-1
分子式	C₁₅H₂₀NNaO₄
分子量	301.31
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Salcaprozate sodium (SNAC) 是一种口服吸收促进剂，有潜力作为口服形式的肝素和胰岛素的递送剂。Salcaprozate sodium 可增加非共价大分子络合引起的亲脂性，从而增加小肠上皮细胞的被动跨细胞渗透。

产品详情

生物活性

Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation.

性状

Solid

体外研究(In Vitro)

SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL.
SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats.
SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident.
SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Riley MGI, et, al. Subchronic oral toxicity of salcaprozate sodium (SNAC) in Sprague-Dawley and Wistar rats. Int J Toxicol. Jul-Aug 2009; 28(4):278-93.
[2]. Twarog C, et, al. Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C 10). Pharmaceutics. 2019 Feb 13; 11(2):78.

溶解度数据	In Vitro: H₂O : 100 mg/mL (331.88 mM; Need ultrasonic)DMSO : 50 mg/mL (165.94 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Salcaprozate sodium

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