OVA Peptide (323-339)

目录号: PL08558 纯度: ≥99%
OVA Peptide (323-339) 代表卵清蛋白(OVA)的T和B细胞表位,这对于BALB/c小鼠的瞬时超敏反应的产生和发展是重要的。
CAS No. :92915-79-2
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中文名称
OVA Peptide (323-339)
中文别名
卵清蛋白肽
英文名称
OVA Peptide (323-339)
英文别名
L-Arginine,L-isoleucyl-L-seryl-L-glutaminyl-L-alanyl-L-valyl-L-histidyl-L-alanyl-L-alanyl-L-histidyl-L-alanyl-L-a-glutamyl-L-isoleucyl-L-asparaginyl-L-a-glutamyl-L-alanylglycyl-;H-ILE-SER-GLN-ALA-VAL-HIS-ALA-ALA-HIS-ALA-GLU-ILE-ASN-GLU-ALA-GLY-ARG-OH;ILE-SER-GLN-ALA-VAL-HIS-ALA-ALA-HIS-ALA-GLU-ILE-ASN-GLU-ALA-GLY-ARG;L-Arginine,L-isoleucyl-L-seryl-L-glutaminyl-L-alanyl-L-valyl-L-histidyl-L-alanyl-L-alanyl-L-hi...;L-Arginine,L-isoleucyl-L-seryl-L-glutaminyl-L-alanyl-L-valyl-L-histidyl-L-alanyl-L-alanyl-L-histidyl-L-alanyl-L-a-glutamyl-L-;OVA (323-339);OVALBUMIN (323-339) (CHICKEN, JAPANESE QUAIL);H2N-ISQAVHAAHAEINEAGR-OH;ISQAVHAAHAEINEAGR;OVA (323-339) (CHICKEN,JAPANESE QUAIL);OvalbuMin (323-339) (chicken,japanese quail) OVA (323-339) (chicken,japanese quail);OVALBUMIN CHICKEN (323-339);L-Isoleucyl-L-seryl-L-glutaminyl-L-alanyl-L-valyl-L-histidyl-L-alanyl-L-alanyl-L-histidyl-L-alanyl-L-α-glutamyl-L-isoleucyl-L-asparaginyl-L-α-glutamyl-L-alanylglycyl-L-arginine (ACI);L;102: PN: WO2009086539 SEQID: 76 unclaimed protein;105: PN: WO2012066495 SEQID: 118 unclaimed protein;107: PN: WO2010068680 SEQID: 91 claimed sequence;10: PN: US20080241228 SEQID: 10 claimed protein;10: PN: US8530153 SEQID: 10 unclaimed protein;10: PN: WO2012054584 SEQID: 10 claimed protein;114: PN: US20060002947 SEQID: 131 unclaimed protein;11: PN: WO03015716 SEQID: 3 claimed protein;11: PN: WO2012027200 SEQID: 11 unclaimed sequence;128: PN: US20090093050 SEQID: 137 unclaimed protein;12: PN: JP2008056647 SEQID: 12 claimed protein;130: PN: WO2011026122 SEQID: 138 unclaimed protein;130: PN: WO2011026132 SEQID: 138 unclaimed protein;133: PN: US20120178139 SEQID: 87 unclaimed sequence;134: PN: WO2011040978 PAGE: 50 unclaimed sequence;14: PN: WO2009101207 SEQID: 14 unclaimed sequence;15: PN: US20100278814 SEQID: 17 unclaimed protein;161: PN: WO2013044419 SEQID: 187 unclaimed protein;168: PN: US20120076808 SEQID: 187 unclaimed protein;16: PN: WO2013089252 SEQID: 16 unclaimed protein;18: PN: WO0072876 SEQID: 18 unclaimed protein;18: PN: WO2014053521 SEQID: 18 claimed sequence;19: PN: WO2009065561 SEQID: 16 unclaimed sequence;1: PN: CN101942013 SEQID: 4 claimed sequence;1: PN: CN104107428 PAGE: 2 claimed sequence;1: PN: EP1908821 SEQID: 1 unclaimed sequence;1: PN: EP2062592 SEQID: 16 unclaimed sequence;1: PN: EP2407177 SEQID: 1 unclaimed protein;1: PN: JP6121597 SEQID: 15 claimed sequence;1: PN: US20040253632 SEQID: 1 claimed protein;1: PN: US20200072837 SEQID: 10 claimed sequence;1: PN: WO03006055 FIGURE: 1 unclaimed protein;1: PN: WO2004069182 SEQID: 3 unclaimed protein;1: PN: WO2008059900 PAGE: 11 claimed sequence;1: PN: WO2008150868 SEQID: 1 unclaimed sequence;1: PN: WO2009023055 SEQID: 1 unclaimed sequence;1: PN: WO2009035600 SEQID: 1 unclaimed sequence;1: PN: WO2012150478 SEQID: 1 unclaimed protein;1: PN: WO2016021605 SEQID: 17 claimed sequence;1: PN: WO2023068376 SEQ...
Cas No.
92915-79-2
分子式
C74H120N26O25
分子量
1773.90
包装储存
Sealed storage, away from moisture and lightPowder -80°C 2 years;-20°C 1 year
详情描述
OVA Peptide (323-339) 代表卵清蛋白(OVA)的T和B细胞表位,这对于BALB/c小鼠的瞬时超敏反应的产生和发展是重要的。
产品详情
OVA Peptide (323-339) 代表卵清蛋白(OVA)的T和B细胞表位,这对于BALB/c小鼠的瞬时超敏反应的产生和发展是重要的。
生物活性
OVA Peptide (323-339) represents a T and B cell epitope of Ovalbumin (Ova), which is important in the generation and development of immediate hypersensitivity responses in BALB/c mice.
性状
Solid
体外研究(In Vitro)
When pulsed with 0.01 μM of OVA Peptide (323-339), M2-expressing B cells lead to an increase in the number of TH cells mobilizing calcium, compared to M2Y-expressing B cells. To assess if M2-expressing B cells are also able to promote stronger individual responses, we quantified the 405/530 ratio MFI of responding TH cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
OVA Peptide (323-339) represents a T and B cell epitope of OVA, which is important in the generation and development of immediate hypersensitivity responses in BALB/c mice. Daily aerosolization of OVA Peptide (323-339) for 20 minutes over a period of 10 days has been as effective in the stimulation of a serum anti-OVA IgE antibody response as sensitization to native OVA by the same route. After sensitization to native OVA, the majority of the IgE anti-OVA response is directed against OVA Peptide (323-339). Evaluated by hematoxylin/eosin and major basic protein immunohistochemical stainings, OVA and OVA Peptide (323-339) induce similar lung inflammation. Interestingly, significant serum total IgE and OVA-specific IgE are observed in OVA mice when compared to saline control. OVA Peptide (323-339) mice show higher serum OVA-specific IgE, OVA Peptide (323-339)-specific IgE, IL-4 a
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and lightPowder -80°C 2 years;-20°C 1 year
SequenceShortening
ISQAVHAAHAEINEAGR
Sequence
Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg
参考文献
[1]. Fontinha D, et al. Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells. PLoS One. 2015 Nov 6;10(11):e0142540.
[2]. Sun LZ, et al. Comparison between ovalbumin and ovalbumin peptide 323-339 responses in allergic mice: humoral and cellular aspects. Scand J Immunol. 2010 May;71(5):329-35.
溶解度数据
In Vitro: H2O : ≥ 50 mg/mL (28.19 mM)配制储备液
搜索质检报告(COA)
[1]. Fontinha D, et al. Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells. PLoS One. 2015 Nov 6;10(11):e0142540.
[2]. Sun LZ, et al. Comparison between ovalbumin and ovalbumin peptide 323-339 responses in allergic mice: humoral and cellular aspects. Scand J Immunol. 2010 May;71(5):329-35.

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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