Trofinetide

目录号: PL08553 纯度: ≥99%
Trofinetide (NNZ-2566) 是内源性 N 末端三肽甘氨酸-脯氨酸-谷氨酸 (GPE) 的合成类似物,已经显示在脑损伤的动物模型中具有神经保护作用。
CAS No. :853400-76-7
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中文名称
Trofinetide
英文名称
Trofinetide
英文别名
L-Glutamic acid, glycyl-2-methyl-L-prolyl-;Trofinetide
Cas No.
853400-76-7
分子式
C13H21N3O6
分子量
315.32
包装储存
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
详情描述
Trofinetide (NNZ-2566) 是内源性 N 末端三肽甘氨酸-脯氨酸-谷氨酸 (GPE) 的合成类似物,已经显示在脑损伤的动物模型中具有神经保护作用。
产品详情
Trofinetide (NNZ-2566) 是内源性 N 末端三肽甘氨酸-脯氨酸-谷氨酸 (GPE) 的合成类似物,已经显示在脑损伤的动物模型中具有神经保护作用。
生物活性
Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury.
性状
Solid
体内研究(In Vivo)
Trofinetide (NNZ-2566) suppresses penetrating ballistic-like brain injury (PBBI) induced inflammatory cell infiltration at 3 days following PBBI as compare to vehicle treatment. Trofinetide treatment significantly reduces the elevation of IL-6 (79%), E-selectin (81%), IL-1β (76%) and TNF-α (72%) mRNA levels in the injured hemisphere at 12 h post-PBBI, with maximal inhibition occurring between 12 h and 24 h. Trofinetide treatment does not affect the PBBI-induced up-regulation of IL-6 expression at any time point, but does produce significant reductions in the injury-induced up-regulation of IL-1β, INF-γ, and TNF-α expression. Trofinetide treatment suppresses IL-1β expression in the injured brain hemisphere for up to 7 days post-PBBI. The high doses of Trofinetide (NNZ-2566) (10 and 100 mg/kg bolus followed by continuous infusion) attenuate non-convulsive seizure (NCS) occurring
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
ClinicalTrial
参考文献
[1]. Wei HH, et al. NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. J Neuroinflammation. 2009 Aug 5;6:19.
[2]. Lu XC, et al. NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats. J Cereb Blood Flow Metab. 2009 Dec;29(12):1924-32.
溶解度数据
In Vitro: H2O : 110 mg/mL (348.85 mM; Need ultrasonic)H2O : ≥ 50 mg/mL (158.57 mM)DMSO : 25 mg/mL (79.28 mM; Need ultrasonic)
搜索质检报告(COA)
[1]. Wei HH, et al. NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. J Neuroinflammation. 2009 Aug 5;6:19.
[2]. Lu XC, et al. NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats. J Cereb Blood Flow Metab. 2009 Dec;29(12):1924-32.

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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