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R162

目录号: PL08519 纯度: ≥98%

R162 是一种有效的谷氨酸脱氢酶 (GDH1/GLUD1) 抑制剂，具有抗癌的作用。

CAS No. :64302-87-0

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PL08519-5mg	5mg	¥723.00	请登录
PL08519-10mg	10mg	¥1125.00	请登录
PL08519-25mg	25mg	¥2175.00	请登录
PL08519-50mg	50mg	¥3285.00	请登录
PL08519-100mg	100mg	¥4715.00	请登录
PL08519-200mg	200mg	询价	询价
PL08519-500mg	500mg	¥9775.00	请登录
PL08519-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1555.00	请登录
PL08519-1 mL x 10 mM (in DMSO)		¥692.00	请登录

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中文名称	R162
中文别名	R162;化合物R162
英文名称	R162
英文别名	9,10-ANTHRACENEDIONE, 1-HYDROXY-2-(2-PROPENYL)-;R162;R-162;R 162;R162, >98%;2-Allyl-1-hydroxy-9,10-anthraquinone;9,10-Anthracenedione, 1-hydroxy-2-(2-propen-1-yl)-
Cas No.	64302-87-0
分子式	C₁₇H₁₂O₃
分子量	264.28
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	R162 是一种有效的谷氨酸脱氢酶 (GDH1/GLUD1) 抑制剂，具有抗癌的作用。

产品详情	R162 是一种有效的谷氨酸脱氢酶 (GDH1/GLUD1) 抑制剂，具有抗癌的作用。
生物活性	R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1), with anti-cancer properties.
性状	Solid
体外研究(In Vitro)	Inhibition of GDH1 activity by R162 treatment results in decreased intracellular fumarate levels, attenuated GPx activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells, which can be significantly rescued by methyl-α-KG treatment as well as by antioxidant NAC. R162 inhibits cell proliferation and tumor growth potential of human cancer cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	R162 (30 mg/kg/day, i.p.) does not result in a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties in xenograft tumor mouse models. R162 (20 mg/kg/day) results in significantly decreased tumor growth and masses in mice compared with control mice and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Jin L, et al. Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell. 2015 Feb 9;27(2):257-70.

溶解度数据	In Vitro: DMF : 6.25 mg/mL (23.65 mM; ultrasonic and warming and heat to 60°C)DMSO : 5.2 mg/mL (19.68 mM; Need ultrasonic)Ethanol : 2 mg/mL (7.57 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (ultrasonic) (insoluble)

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[1]. Jin L, et al. Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell. 2015 Feb 9;27(2):257-70.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

R162

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