CB-6644|2316817-88-4|-陌孚医药/Medlife

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CB-6644

目录号: PL08512 纯度: ≥98%

CAS No. :2316817-88-4

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中文名称	CB-6644
中文别名	化合物CB-6644
英文名称	CB-6644
英文别名	5-Chloro-2-ethoxy-4-fluoro-N-[4-[[3-(methoxymethyl)-1-oxo-6,7-dihydro-5H-pyrazolo[1,2-a][1,2]benzodi;5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-oxobutyl)benzamide;BCP31705;CB 6644;CB6644;CB-6644;oxobutyl)benzamide;oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-;a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-;5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-;5-chloro-2-ethoxy-4-fluoro-N-[4-[[3-(methoxymethyl)-1-oxo-6,7-dihydro-5H-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxobutyl]benzamide;CID 137333455;CB-6644 (CB6644;Chb-M';CB6644,CB-6644,Inhibitor,CB 6644,inhibit;Benzamide, 5-chloro-N-[4-[[6,7-dihydro-3-(methoxymethyl)-1-oxo-1H,5H-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxobutyl]-2-ethoxy-4-fluoro-
Cas No.	2316817-88-4
分子式	C₂₉H₃₄ClFN₄O₅
分子量	573.06
包装储存	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	CB-6644 一种选择性的 RUVBL1/2 复合体抑制剂。抑制 RUVBL1/2 的 ATP 酶活性，IC₅₀ 为 15 nM。具有抗癌活性。
生物活性	CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC 50 of 15 nM.
性状	Solid
体外研究(In Vitro)	CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells. CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (including HCT116, NCI-1975, and HT29 cells) with an EC50 range of 41 to 785 nM. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay
体内研究(In Vivo)	CB-6644 (150 mg/kg, oral administration, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models, 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models) has antitumor activity in xenograft tumor models with tumor growth inhibitions (TGIs) of 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Assimon VA, et al. CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity. ACS Chem Biol. 2019 Feb 15;14(2):236-244.

溶解度数据	In Vitro: DMSO : 100 mg/mL (174.50 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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