TRi-1|246020-68-8|-陌孚医药/Medlife

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TRi-1

目录号: PL08506 纯度: ≥99%

CAS No. :246020-68-8

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中文名称	TRi-1
英文名称	TRi-1
英文别名	TRi-1;MLS000851064;2-[(4-chlorophenyl)sulfonyl]-6-methoxy-3-nitropyridine;SMR000457307;2-((4-Chlorophenyl)sulfonyl)-6-methoxy-3-nitropyridine;TRi 1;TRi1;2-(4-chlorophenyl)sulfonyl-6-methoxy-3-nitro-pyridine;2-(4-chlorophenyl)sulfonyl-6-methoxy-3-nitropyridine;BDBM47478;cid_2801235;REGID_for_CID_2801235;HMS2781O05;KUC105319N;BCP30860
Cas No.	246020-68-8
分子式	C₁₂H₉ClN₂O₅S
分子量	328.73
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	TRi-1 是有效的、特异性的、不可逆的胞质硫氧还蛋白还原酶1 (TXNRD1) 的抑制剂，其 IC₅₀ 值为 12 nM。TRi-1 有抗肿瘤活性，且线粒体毒性很小。
生物活性	TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC 50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy.
性状	Solid
IC50 & Target[1][2]	IC50: 12 nM (TXNRD1).
体外研究(In Vitro)	TRi-1 (0.679 and 6.79 μM; 6 h) has no effect on cellular glutathione (GSH) concentrations in FaDu cells, efficiently activates JNK and p38 phosphorylation. TRi-1 (2 μM) irreversibly inhibit TXNRD1 in an NADPH-dependent manner. TRi-1 (0.1-10 μM; 0-10 h) increases cellular H2O2 production in cultured FaDu cells in a concentration- and time-dependent manner. TRi-1 (10 nM-100 μM; 48 h) shows cytotoxicity toward cancer cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	TRi-1 (10 mg/kg; i.v.; twice a day for 4 days or 5 mg/kg; i.p.; twice a week for 3 weeks) impaires growth and viability of human tumor xenografts and syngeneic mouse tumors. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Stafford WC, et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444.

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (190.13 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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