Talaporfin sodium
目录号: PL08491 纯度: ≥99%
CAS No. :220201-34-3
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中文名称
Talaporfin sodium
中文别名
他拉泊芬钠
英文名称
Talaporfin sodium
英文别名
Talaporfin sodium;Tetrasodium (2S)-2-((((7S,8S)-3-carboxylato-7-(2-carboxylatoethyl)-13-ethenyl-18-ethyl-2,8,12,17-tetramethyl-7,8-dihydroporphyrin-5-yl)acetyl)amino)butanedioate;tetrasodium,(2S)-2-[[2-[(2S,3S)-7-carboxylato-3-(2-carboxylatoethyl)-17-ethenyl-12-ethyl-2,8,13,18-tetramethyl-2,3,23,24-tetrahydroporphyrin-5-yl]acetyl]amino]butanedioate;(+)-tetrasodium (2S,3S)-18-carboxylato-20-[N-(S)-1,2-dicarboxylatoethyl]-carbamoylmethyl-13-ethyl-3,7,12,17-tetramethyl-8-vinylchlorin-2-propanoate;Aptocine;Laserphyrin;Laserphyrin (TN);LS-11;ME2906;mono-L-aspartin-chlorin e6;Mono-L-aspartyl chlorin e6;mono-L-aspartyl chlorin e6 tetrasodium salt;NPe6;TalaporfinsodiuMsalt;talaporphin sodium;Taporfin sodium
Cas No.
220201-34-3
分子式
C38H37N5Na4O9
分子量
799.69
包装储存
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
产品详情
Talaporfin (ME2906) sodium 是一种基于二氢卟酚的光敏剂。Talaporfin sodium 可通过光动力疗法(PDT)用于各种癌症的研究。
生物活性
Talaporfin (ME2906) sodium is a chlorin based photosensitizer. Talaporfin sodium can be used for the research of various cancers by using photodynamic therapy (PDT).
性状
Solid
体内研究(In Vivo)
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs) .
Labeling in vivo:
1. Use the rat brain tumor model produced by the inoculation of resuspended tumor cells into the frontal rat brain. Feed animals according to your normal protocol.
2. Intravenous injection of 5 mg/kg body weight talaporfin sodium, the concentration of the talaporfin sodium is 5 mg/1 ml 0.9% saline.
3. For the control group, intraperitoneal injection of 100 mg/kg body weight 5-ALA, the concentration of the 5-ALA is 20 mg/1 ml 0.9% saline.
4. Obtain the tissue samples corresponding to the tumor (or edema) brain tissue with 5 mm thickness.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
ClinicalTrial
参考文献
[1]. Takao Tsurubuchi, et al. The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema--in vivo kinetic study of 5-aminolevulinic acid and talaporfin sodium. Photodiagnosis Photodyn Ther. 2009 Mar;6(1):19-27.
溶解度数据
In Vitro: H2O : 25 mg/mL (31.26 mM; Need ultrasonic)DMSO : 2 mg/mL (2.50 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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