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Sardomozide dihydrochloride

目录号: PL08483 纯度: ≥98%

Sardomozide dihydrochloride 是一种 S-腺苷甲硫氨酸脱羧酶 (SAMDC) 抑制剂，其 IC50 值为 5 nM。

CAS No. :138794-73-7

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中文名称	Sardomozide dihydrochloride
中文别名	2-[4-(氨基亚胺甲基)-2,3-二氢-1H-茚-1-亚基]肼甲脒二盐酸盐
英文名称	Sardomozide dihydrochloride
英文别名	(E)-1-((Diaminomethylene)hydrazono)-2,3-dihydro-1H-indene-4-carboximidamide;CGP 48664A;Sardomozide dihydrochloride
Cas No.	138794-73-7
分子式	C₁₁H₁₄N₆
分子量	230.27
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Sardomozide dihydrochloride 是一种 S-腺苷甲硫氨酸脱羧酶 (SAMDC) 抑制剂，其 IC50 值为 5 nM。

产品详情	Sardomozide dihydrochloride 是一种 S-腺苷甲硫氨酸脱羧酶 (SAMDC) 抑制剂，其 IC₅₀ 值为 5 nM。
生物活性	Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC 50 of 5 nM.
性状	Solid
IC50 & Target[1][2]	IC50: 5 nM (SAMDC)
体外研究(In Vitro)	Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7. [2]. Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90.

溶解度数据	In Vitro: DMSO : 10 mg/mL (32.98 mM; ultrasonic and warming and heat to 60°C)H₂O : 3.85 mg/mL (12.70 mM; ultrasonic and warming and heat to 60°C)

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[1]. Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7.
[2]. Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Sardomozide dihydrochloride

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