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FR054

目录号: PL08452 纯度: ≥96.0%

FR054 是 HBO 酶 PGM3 的抑制剂，具有明显的抗乳腺癌活性。

CAS No. :35954-65-5

商品编号	规格	价格	会员价
PL08452-5mg	5mg	¥240.00	请登录
PL08452-10mg	10mg	¥363.00	请登录
PL08452-50mg	50mg	¥788.00	请登录
PL08452-100mg	100mg	¥1125.00	请登录
PL08452-200mg	200mg	¥1685.00	请登录
PL08452-500mg	500mg	询价	询价
PL08452-10mM*1mLinDMSO	10mM*1mLinDMSO	¥884.00	请登录
PL08452-1 mL x 10 mM (in DMSO)		¥172.00	请登录

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中文名称	FR054
中文别名	(3aR)-2-甲基-5alpha-(乙酰氧基甲基)-6beta,7alpha-二乙酰氧基-3Aalpha,6,7,7Aalpha-四氢-5H-吡喃并[3,2-d]恶唑;8-( 3 - 羧基- 1 - 甲基丙氨)- 6 - 甲氧基喹唑啉
英文名称	FR054
英文别名	2-Methyl-4,5-(3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyrano)-Δ2-oxazoline;LogP;2-Methyl-4,5-(3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyrano)-?2-oxazoline;(3aR)-2-Methyl-5α-(acetoxymethyl)-6β,7α-diacetoxy-3aα,6,7,7aα-tetrahydro-5H-pyrano[3,2-d]oxazole;[(3aR,5R,6S,7R,7aR)-6,7-diacetyloxy-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]oxazol-5-yl]methyl acetate;2-METHYL-4,5-(3,4,6-TRI-O-ACETYL-2-DEOXY-A-D-GLUCOPYRANO)-2-OXAZOLINE;2-Methyl-4,5-(3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyrano)-∆2-oxazoline;FR054
Cas No.	35954-65-5
分子式	C₁₄H₁₉NO₈
分子量	329.30
包装储存	Pure form -20°C 3 years；4°C 2 years
详情描述	FR054 是 HBO 酶 PGM3 的抑制剂，具有明显的抗乳腺癌活性。

产品详情	FR054 是 HBO 酶 PGM3 的抑制剂，具有明显的抗乳腺癌活性。
生物活性	FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect.
性状	Oil
体外研究(In Vitro)	FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects. FR054 (250?μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells. FR054 induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptotic cell death. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	FR054 (1000?mg/kg, ip) suppresses cancer growth in MDA-MB-231 xenograft mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice were subcutaneously injected with MDA-MB-231 cells.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Pure form -20°C 3 years；4°C 2 years
参考文献	[1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.

溶解度数据	In Vitro: DMSO : 100 mg/mL (303.67 mM; Need ultrasonic)配制储备液

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[1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

FR054

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