NSC139021|1147-56-4|-陌孚医药/Medlife

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NSC139021

目录号: PL08457 纯度: ≥99%

CAS No. :1147-56-4

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中文名称	NSC139021
中文别名	1-(2-联氮噻吩)-2-萘酚;1-(2-噻唑基偶氮)-2-萘酚;1-(2-噻唑偶氮)-2-萘酚[过渡金属类用分光光度试剂];2-氯吡啶;1-(2'-噻唑偶氮)-2-萘酚;1-(2-噻唑偶氮)-2-萘酚;2-(2-羟基-1-萘偶氮)噻唑;1-(2'-噻唑基偶氮)-2-萘酚;2-(2-羟基-1-萘基偶氮)噻唑;1-(2’-噻唑偶氮)-2-萘酚;TAN[=1-(2-噻唑偶氮)-2-萘酚][过渡金属类用分光光度试剂];TAN[=1-(2-噻唑偶氮)-2-萘酚](>99.0%(T))
英文名称	NSC139021
英文别名	1-(2-Thiazolylazo)-2-naphthol;TAN;1,2-thiazoylazo-2-naphthol;1-thiazol-2-ylazo-naphthalen-2-ol;1-(1,3-Thiazolyl-2-azo)-2-naphthol;2-Naphthalenol, 1-(2-thiazolylazo)-;1-(2-Thiazoylazo)-2-naphthol;NSC139021;MLS000738280;1-(Thiazol-2-ylazo)-2-naphthol;2-Naphthol, 1-(2-thiazolylazo)-;2-(2-Hydroxy-1-naphthylazo)thiazole;(1Z)-1-(1,3-thiazol-2-ylhydrazinylidene)naphthalen-2-one;SMR000528601;1-(1,3-thiazol-2-yldiazenyl)-2-naphthol;2-Naphthalenol, 1-[2-(2-thiazolyl)diazenyl]-;(1Z)-1-(2-thiazolylhydrazinylidene)-2-naphthalenone;2-Naphthalenol, 1-(2-(2-thiazolyl)diazenyl)-;EINE;ERGi-USU;SCHEM;2-(2-Hydroxy-1-naphthylazo)thiazole, TAN;Nitrilotantalum(III);1-(Thiazole-2-ylazo)-2-naphthol;1-(Thiazole-2-ylazo)naphthalene-2-ol;1-[(Thiazole-2-yl)azo]-2-naphthol;TAN [=1-(2-Thiazolylazo)-2-naphthol];TAN [=1-(2-Thiazolylazo)-2-naphthol] [Spectrophotometric reagent for transition metals]
Cas No.	1147-56-4
分子式	C₁₃H₉N₃Os
分子量	255.30
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	NSC139021 (ERGi-USU) 是ERG阳性癌细胞生长的高度选择性抑制剂，抑制不同细胞系的 IC₅₀ 值为 30 到400 nM。
生物活性	NSC139021 (ERGi-USU) is a highly selective inhibitor for the growth of ERG-positive cancer cells with IC 50 s ranging from 30 to 400 nM.
性状	Solid
IC50 & Target[1][2]	IC50: 30 to 400 nM (ERG-positive cancer cells)
体外研究(In Vitro)	NSC139021 selectively inhibits growth of ERGpositive cancer cell lines with minimal effect on normal prostate or endothelial cells or ERG-negative tumor cell lines. The IC50 of NSC139021 for cell growth inhibition of responsive cell lines range between 30 nM to 400 nM. Combination of NSC139021 with enzalutamide shows additive effects in inhibiting growth of VCaP cells. A screen of kinases reveal that NSC139021 directly bound the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	NSC139021 treatment inhibits growth of ERG-positive VCaP tumor xenografts with no apparent toxicity. Significant (P<0.05, P<0.005) inhibition of tumor growth is noted at day 26 in treatment groups indicating 44% (100 mg/kg) and 65% (150 mg/kg) reduction of tumor burden. At 100 mg/kg and 150 mg/kg, no apparent toxicity including weight loss, lethargy, diarrhea, loss of appetite, respiratory distress, or overall drug related toxicity is observed. . has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Mohamed AA, et al. Identification of a small molecule that selectively inhibits ERG-positive cancer cell growth. Cancer Res. 2018 Apr 30. pii: canres.2949.2017.

溶解度数据	In Vitro: DMSO : ≥ 62 mg/mL (242.85 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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