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(Z)-Mirin

目录号: PL08473 纯度: ≥99%

Mirin是小分子MRN（Mre11，Rad50，和Nbs1）复合物的抑制剂。

CAS No. :1198097-97-0

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PL08473-50mg	50mg	¥1965.00	请登录
PL08473-100mg	100mg	¥2965.00	请登录
PL08473-200mg	200mg	¥4655.00	请登录
PL08473-500mg	500mg	¥7165.00	请登录
PL08473-1g	1g	询价	询价
PL08473-1 mL x 10 mM (in DMSO)	1 mL x 10 mM (in DMSO)	¥485.00	请登录

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中文名称	(Z)-Mirin
中文别名	(5Z)-2-氨基-5-[(4-羟基苯基)亚甲基]-4(5H)-噻唑酮
英文名称	(Z)-Mirin
英文别名	Mirin;(Z)-5-(4-hydroxybenzylidene)-2-imino-4-oxo-thiazolidine;5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one;Q27166472;2-amino-5-[(4-hydroxyphenyl)methylidene]-4-thiazolone;[Z-5-(4-hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one];(Z)-Mirin
Cas No.	1198097-97-0
分子式	C₁₀H₈N₂O₂S
分子量	220.25
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Mirin是小分子MRN（Mre11，Rad50，和Nbs1）复合物的抑制剂。

产品详情	Mirin是小分子MRN（Mre11，Rad50，和Nbs1）复合物的抑制剂。
生物活性	Mirin is a small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex. Target: in vitro: Mirin was shown to block Mre11 exonuclease activity and MRN-dependent ATM activation, and to inhibit the ionizing radiation-induced G2/M checkpoint and homologous recombination in mammalian cells. Mirin inhibition of ATM activation is independent of Mre11 nuclease inhibition since the M(HN)RN and M(HL/DV)RN mutant complexes are inhibited equivalently to the wild-type enzyme despite the fact that they are nuclease-deficient. The effects of Mirin have been ascribed to its effects on Mre11 nuclease activity, but as we show here, Mirin is inhibitory of MRN function independent of the nuclease activity of the complex. [2] Addition of the Mre11 inhibitor Mirin to egg extracts and mammalian cells reduces RCC1 association with mitotic chromosomes. HeLa cells expressing Histone H2B-EYFP were treated w
性状	Solid
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Rozier L, et al. The MRN-CtIP pathway is required for metaphase chromosome alignment. Mol Cell. 2013 Mar 28;49(6):1097-107. [2]. Lee JH, et al. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem. 2013 May 3;288(18):12840-51.

溶解度数据	In Vitro: DMSO : ≥ 31 mg/mL (140.75 mM)配制储备液

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[1]. Rozier L, et al. The MRN-CtIP pathway is required for metaphase chromosome alignment. Mol Cell. 2013 Mar 28;49(6):1097-107.
[2]. Lee JH, et al. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem. 2013 May 3;288(18):12840-51.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

(Z)-Mirin

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