SGN-2FF

目录号: PL08460 纯度: ≥99.0%
SGN-2FF 是一种有效的,具有口服活性的岩藻糖基化抑制剂,抑制岩藻糖基转移酶 (fucosyltransferase) 的活性,具有抗肿瘤活性。
CAS No. :2089647-47-0
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中文名称
SGN-2FF
英文名称
SGN-2FF
英文别名
2-Deoxy-2-fluoro-L-fucose;SGN-2FF;(3S,4R,5S,6S)-3-Fluoro-6-methyl-tetrahydropyran-2,4,5-triol;(3S,4R,5S,6S)-3-fluoro-6-methyloxane-2,4,5-triol;starbld0000872;NSC803552
Cas No.
2089647-47-0
分子式
C6H11FO4
分子量
166.15
包装储存
Powder -20°C 3 years;4°C 2 years
详情描述
SGN-2FF 是一种有效的,具有口服活性的岩藻糖基化抑制剂,抑制岩藻糖基转移酶 (fucosyltransferase) 的活性,具有抗肿瘤活性。
产品详情
SGN-2FF 是一种有效的,具有口服活性的岩藻糖基化抑制剂,抑制岩藻糖基转移酶 (fucosyltransferase) 的活性,具有抗肿瘤活性。
生物活性
SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity.
性状
Solid
IC50 & Target[1][2]
Fucosyltransferase
体外研究(In Vitro)
SGN-2FF (2-Fluorofucose) is an inhibitor of fucosylation, inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of afucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
SGN-2FF exhibits antitumor activity in multiple mouse tumor models, showing substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
ClinicalTrial
参考文献
[1]. Stephen C. Alley, et al. Abstract DDT02-02: SGN-2FF: A novel small molecule inhibitor of fucosylation with preclinical antitumor activity through multiple immune mechanisms. Cancer Res 2017;77(13 Suppl).
溶解度数据
In Vitro: DMSO : 50 mg/mL (300.93 mM; Need ultrasonic)H2O : 36.67 mg/mL (220.70 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)
[1]. Stephen C. Alley, et al. Abstract DDT02-02: SGN-2FF: A novel small molecule inhibitor of fucosylation with preclinical antitumor activity through multiple immune mechanisms. Cancer Res 2017;77(13 Suppl).

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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