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Oxyphenisatine

目录号: PL08447 纯度: ≥99%

Oxyphenisatine (Oxyphenisatin) 是一种泻药。 Oxyphenisatin acetate是具有抗癌活性的氧联苯沙星的前体药。

CAS No. :125-13-3

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中文名称	Oxyphenisatine
中文别名	酚汀;3,3-二(4-羟基苯基)-2(3H)-吲哚酮;3,3-双(对羟基苯基)氧化吲哚;十九(烷)酸二十四烷酯;酚丁;二酚靛红
英文名称	Oxyphenisatine
英文别名	2H-Indol-2-one,1,3-dihydro-3,3-bis(4-hydroxyphenyl)-;3,3-bis(4-hydroxyphenyl)-1H-indol-2-one;3,3-BIS(P-HYDROXYPHENYL)OXINDOLE;Oxyphenisatin;Oxyphenisatine;3,3-bis-(4-hydroxy-phenyl)-1,3-dihydro-indol-2-one;3,3-bis-(4-hydroxyphenyl)-2-indolinone;3,3-bis(4'-hydroxyphenyl)-2-oxo-2,3-dihydroindole;3,3-bis-(4-hydroxy-phenyl)-indolin-2-one;3,3-bis(p-hydroxyphenyl)-2-indolinone;4,4'-dihydroxydiphenylisatin;diphenolisatin;isatinbisphenol;isolax;lavema;neodrast;recolon;hoscolax;normalax;veripaque;propellax;phenolisatin
Cas No.	125-13-3
分子式	C₂₀H₁₅NO₃
分子量	317.34
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
详情描述	Oxyphenisatine (Oxyphenisatin) 是一种泻药。 Oxyphenisatin acetate是具有抗癌活性的氧联苯沙星的前体药。

产品详情	Oxyphenisatine (Oxyphenisatin) 是一种泻药。 Oxyphenisatin acetate是具有抗癌活性的氧联苯沙星的前体药。
生物活性	Oxyphenisatine (Oxyphenisatin) is a laxative. Oxyphenisatin acetate is the pro-drug of oxyphenisatin with anticancer activity.
性状	Solid
体外研究(In Vitro)	Oxyphenisatin has been shown to have antiproliferative activity. Oxyphenisatin acetate (OXY, NSC 59687) is the pro-drug of oxyphenisatin. OXY inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468 (IC50=0.8, 0.6, 2.1, 1.8 μM). This effect is associated with selective inhibition of translation accompanied by rapid phosphorylation of the nutrient sensing eIF2α kinases, GCN2 and PERK. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Toxicity studies demonstrate that mice tolerate IP administration of OXY at 300 mg/kg once daily or 200 mg/kg twice daily. Administration of OXY at 300 mg/kg IP once daily for 10 days results in significantly smaller tumors from day 33 to day 52. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Morrison BL, et al. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis. Cancer Med. 2013 Oct;2(5):687-700.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (315.12 mM)配制储备液

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[1]. Morrison BL, et al. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis. Cancer Med. 2013 Oct;2(5):687-700.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Oxyphenisatine

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