Ingliforib|186392-65-4|-陌孚医药/Medlife

您当前的位置：

Ingliforib

目录号: PL08400 纯度: ≥99%

CAS No. :186392-65-4

商品编号	规格	价格	会员价
PL08400-5mg	5mg	¥1120.00	请登录
PL08400-10mg	10mg	¥2117.50	请登录
PL08400-25mg	25mg	¥4987.50	请登录
PL08400-50mg	50mg	¥9415.00	请登录
PL08400-100mg	100mg	询价	询价
PL08400-200mg	200mg	询价	询价
PL08400-10mM*1mLinDMSO	10mM*1mLinDMSO	¥5480.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Ingliforib
英文名称	Ingliforib
英文别名	N-{(1S,2R)-1-benzyl-3-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-hydroxy-3-oxopropyl}-5-chloro-1H-indole-2-carboxamide;5-chloro-N-[(2S,3R)-4-[(3S,4R)-3,4-dihydroxypyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-1H-indole-2-carboxamide;Ingliforib;UII7156WLU;(R-(R,S-(cis)))-5-Chloro-N-(3-(3,4-dihydroxy-1-pyrrolidinyl)-2-hydroxy-3-oxo-1-(phenylmethyl)propyl)-1H-indole-2-carboxamide;Ingliforib [USAN:INN];Ingliforib (USAN/INN);DSSTox_CID_27252;DSSTox_RID_82211;DSSTox_GSID_47252;cp368296;AMY16882;Tox21_300206;5-chloro-N-[(2S,3R)-4-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-3-hydroxy-4-ox
Cas No.	186392-65-4
分子式	C₂₃H₂₄ClN₃O₅
分子量	457.91
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Ingliforib (CP 368296) 是一种 glycogen phosphorylase 抑制剂，对肝脏、肌肉和大脑 glycogen phosphorylase 的 IC₅₀ 值分别为 52，352 和 150 nM，具有心脏保护的作用。
生物活性	Ingliforib (CP 368296) is a glycogen phosphorylase inhibitor, with IC 50 s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.
性状	Solid
IC50 & Target[1][2]	IC50: 52 nM (liver Glycogen phosphorylase), 352 nM (Muscle Glycogen phosphorylase), 150 nM (Barin Glycogen phosphorylase)
体外研究(In Vitro)	Ingliforib is a glycogen phosphorylase inhibitor, and inhibits the myocardial GP isoforms (muscle and brain) with IC50s of 352 and 150 nM, respectively, also a potent inhibitor of the liver isoform (IC50 of 52 nM). Ingliforib (0.1, 1, 10 μM) dose-dependently reduces infarct size in the isolated rabbit hearts. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Ingliforib (15 mg/kg) potently reduces infarct size by 52%, and decreases plasma glucose and lactate concentrations in openchest anesthetized rabbits. Ingliforib (15 mg/kg) also inhibits myocardial glycogen phosphorylase a (GPa) and total glycogen phosphorylase (GP) activity in anesthetized rabbits. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Tracey WR, et al. Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor. Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1177-84.

溶解度数据	In Vitro: DMSO : 130 mg/mL (283.90 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation