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Ibuprofen piconol

目录号: PL08354 纯度: ≥98%

Ibuprofen picono 是一种非甾体抗炎 (NSAID) 药物，用于局部缓解原发性热灼伤和晒伤。

CAS No. :64622-45-3

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中文名称	Ibuprofen piconol
中文别名	布洛芬吡甲酯;皮考布洛芬;匹美诺芬
英文名称	Ibuprofen piconol
英文别名	Benzeneacetic acid, a-methyl-4-(2-methylpropyl)-,2-pyridinylmethyl ester;2-pyridylmethyl 2-(4-isobutylphenyl)propionate;Ibuprofen piconol;2-(p-Isobutylphenyl)propionic acid 2-pyridylmethyl ester;2-Pyridylmethyl 2-(p-(2-methylpropyl)phenyl)propionate;alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid 2-pyridinylmethyl ester;BE 100;Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-, 2-py;Pimeprofen;Propionic acid, 2-(p-isobutylphenyl)-, 2-pyridylmethyl ester;Staderm;U 75630;UNII-B0F91K5U4N;Vesicum;Ibuprofen piconol [USAN:JAN];pyridin-2-ylmethyl 2-(4-isobutylphenyl)propanoate;pyridin-2-ylmethyl 2-[4-(2-methylpropyl)phenyl]propanoate;2-pyridylmethyl 2-(4-isobutylphenyl)
Cas No.	64622-45-3
分子式	C₁₉H₂₃NO₂
分子量	297.39
包装储存	Pure form -20°C 3 years；4°C 2 years
详情描述	Ibuprofen picono 是一种非甾体抗炎 (NSAID) 药物，用于局部缓解原发性热灼伤和晒伤。

产品详情	Ibuprofen picono 是一种非甾体抗炎 (NSAID) 药物，用于局部缓解原发性热灼伤和晒伤。
生物活性	Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.
性状	Liquid
体外研究(In Vitro)	Ibuprofen piconol is a chemically stable, slightly hygroscopic liquid that strongly partitions into the oil phase and shows no indication of surface activity. This drug has very limited solubility in water (16.5 ppm), modest solubility in glycerol (16.4 mg/mL), and is miscible with less polar organics except for silicone fluids. Varying the initial concentration of ibuprofen piconol does not alter the hydrolysis half-life (concentration range from 50 to 200 μg/mL). The anticoagulant used alters the hydrolysis half-life. For plasma, the half-life is shortest when no anticoagulant is present (t1/2=2.5 h) and longer with the presence of anticoagulants; t1/2=8.0 h for citrate, t1/2=15.5 h for heparin and t1/2=161.8 h for EDTA. Red blood cell uptake of ibuprofen piconol is minimal and ranges from 0.4 to 4.1% over the ibuprofen piconol con
体内研究(In Vivo)	When ibuprofen piconol is applied topically, only ibuprofen and its metabolites are observed in plasma and urine. The conversion of ibuprofen piconol to ibuprofen appears to be extremely rapid in vivo. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Pure form -20°C 3 years；4°C 2 years
参考文献	[1]. Pesheck CV, et al. Preformulation characterization of topical Ibuprofen Piconol. Drug Development and Industrial Pharmacy Vol. 19 , Iss. 15,1993 [2]. Christensen JM, et al. Ibuprofen piconol hydrolysis in vitro in plasma, whole blood, and serum using different anticoagulants. J Pharm Sci. 1991 Jan;80(1):29-31.

溶解度数据	In Vitro: DMSO : ≥ 50 mg/mL (168.13 mM)配制储备液

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[1]. Pesheck CV, et al. Preformulation characterization of topical Ibuprofen Piconol. Drug Development and Industrial Pharmacy Vol. 19 , Iss. 15,1993
[2]. Christensen JM, et al. Ibuprofen piconol hydrolysis in vitro in plasma, whole blood, and serum using different anticoagulants. J Pharm Sci. 1991 Jan;80(1):29-31.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Ibuprofen piconol

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