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NS-3-008 hydrochloride

目录号: PL08352 纯度: ≥99%

NS-3-008 hydrochloride 是一种口服活性的 G0s2 转录抑制剂，IC50 为 2.25 μM。NS-3-008 hydrochloride 可用于慢性肾脏疾病。

CAS No. :1172854-54-4

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PL08352-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1414.00	请登录
PL08352-1 mL x 10 mM (in DMSO)		¥414.00	请登录

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中文名称	NS-3-008 hydrochloride
英文名称	NS-3-008 hydrochloride
英文别名	BCP33849;1-Benzyl-3-hexylguanidine hydrochloride;3-benzyl-1-hexylguanidine hydrochloride;N-BENZYL-N'-HEXYLGUANIDINE HYDROCHLORIDE;NS-3-008 hydrochloride
Cas No.	1172854-54-4
分子式	C₁₄H₂₄ClN₃
分子量	269.81
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	NS-3-008 hydrochloride 是一种口服活性的 G0s2 转录抑制剂，IC50 为 2.25 μM。NS-3-008 hydrochloride 可用于慢性肾脏疾病。

产品详情	NS-3-008 hydrochloride 是一种口服活性的 G0s2 转录抑制剂，IC₅₀ 为 2.25 μM。NS-3-008 hydrochloride 可用于慢性肾脏疾病。
生物活性	NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC 50 of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease.
性状	Solid
IC50 & Target[1][2]	IC50: 2.25 μM (G0s2)
体外研究(In Vitro)	NS-3-008 binds to Hsd17b4; knockdown of Hsd17b4 decreased G0s2 mRNA levels, whereas overexpression of Hsd17b4 induced G0s2 mRNA expression. The inhibitory effects of NS-3-008 are blocked by knockdown of Hsd17b4 or deletion of the Stat5 binding site in the G0s2 promoter. NS-3-008 decreases the nuclear phosphorylation of Stat5. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	NS-3-008 (5 mg/kg; oral administration; daily; for 4 weeks; wild-type 5/6Nx mice) treatment results in decreased levels of G0s2 and Ccl2 mRNA in the kidneys. The phosphorylation of Stat5 and p65 protein is decreased, and SUN concentrations and renal caspase 3/7 activity decreased in 5/6Nx mice treated with NS-03-08. The F4/80-positive area and F4/80 protein levels are decreased in 5/6Nx mice treated with NS-3-008. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Matsunaga N, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov;13:262-273.

溶解度数据	In Vitro: DMSO : 125 mg/mL (463.29 mM; Need ultrasonic)H₂O : 125 mg/mL (463.29 mM; Need ultrasonic)配制储备液

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[1]. Matsunaga N, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov;13:262-273.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

NS-3-008 hydrochloride

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