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Sortin1

目录号: PL08341 纯度: ≥98%

Sortin1是液泡蛋白分选抑制剂，植物和酵母可溶性和膜的液泡标记分子。

CAS No. :503837-98-7

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中文名称	Sortin1
中文别名	Sortin1
英文名称	Sortin1
英文别名	Sortin1;Sortin-1;C26H19NO6;4-[5-(4-Carboxy-phenyl)-furan-2-yl]-2-methyl-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylic acid methyl ester;4-(5-[3-(Methoxycarbonyl)-2-methyl-5-oxo-4,5-dihydro-1H-indeno[1,2-B]pyridin-4-yl]-2-furyl)benzoic acid;4-{5-[3-(methoxycarbonyl)-2-methyl-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridin-4-yl]-2-furyl}benzoic acid;CBMicro_004547;Oprea1_166104;Oprea1_813658;HMS2344I17;SMSF0016161;3259AH;STL415961;CB06472
Cas No.	503837-98-7
分子式	C₂₆H₁₉NO₆
分子量	441.43
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Sortin1是液泡蛋白分选抑制剂，植物和酵母可溶性和膜的液泡标记分子。

产品详情	Sortin1是液泡蛋白分选抑制剂，植物和酵母可溶性和膜的液泡标记分子。
生物活性	Sortin1 is a chemical genetic-hit molecule that causes specific mislocalization of plant and yeast-soluble and membrane vacuolar markers. IC50 value: Target: Vacuolar markers in vitro: In Arabidopsis seedlings, application of Sortin1 and -2 led to reversible defects in vacuole biogenesis and root development. Sortin1 was found to redirect the vacuolar destination of plant carboxypeptidase Y and other proteins in Arabidopsis suspension cells and cause these proteins to be secreted. Sortin1 treatment of whole Arabidopsis seedlings also resulted in carboxypeptidase Y secretion, indicating that the drug has a similar mode of action in cells and intact plants [1]. Structure-activity relationship studies conducted in Arabidopsis revealed the structural requirements for Sortin1 bioactivity and demonstrated that overlapping Sortin1 substructures can be used to discriminate between
性状	Solid
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Zouhar J, et al. Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9497-501. [2]. Rosado A, et al. Sortin1-hypersensitive mutants link vacuolar-trafficking defects and flavonoid metabolism in Arabidopsis vegetative tissues. Chem Biol. 2011 Feb 25;18(2):187-97.

溶解度数据	In Vitro: DMSO : 100 mg/mL (226.54 mM; Need ultrasonic)配制储备液

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[1]. Zouhar J, et al. Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9497-501.
[2]. Rosado A, et al. Sortin1-hypersensitive mutants link vacuolar-trafficking defects and flavonoid metabolism in Arabidopsis vegetative tissues. Chem Biol. 2011 Feb 25;18(2):187-97.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Sortin1

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