IP7e
目录号: PL08367 纯度: ≥99%
CAS No. :500164-74-9
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中文名称
IP7e
中文别名
化合物 T27620
英文名称
IP7e
英文别名
Isoxazolo[4,5-c]pyridin-4(5H)-one,6-[4-[(2-methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-;IP7E;6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one;6-{4-[(2-methoxyethoxy)methyl]phenyl}-5-methyl-3-phenyl-4H,5H-[1,2]oxazolo[4,5-c]pyridin-4-one;Isoxazolo[4,5-c]pyridin-4(5H)-one, 6-[4-[(2-methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-;isoxazolo-pyridinone 7e;IP7e;6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenylisoxazolo[4,5-c]pyridin-4(5H)-one (ACI);IP 7e
Cas No.
500164-74-9
分子式
C23H22N2O4
分子量
390.43
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
IP7e 是一种有效的、可透过血脑屏障,并具有口服活性的 Nurr1 激活剂,EC50 为 3.9 nM。
生物活性
IP7e is a potent, brain-penetrant and orally active Nurr1 activator with an EC 50 value of 3.9 nM.
性状
Solid
IC50 & Target[1][2]
EC50: 3.9 nM (Nurr1)
体内研究(In Vivo)
IP7e (Isoxazolo-pyridinone 7e; 10 mg/kg; oral gavage; twice a day) preventive treatment reduces the incidence and the severity of a MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE). IP7e attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Samuel Hintermann, et al. Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg Med Chem Lett. 2007 Jan 1;17(1):193-6.
[2]. Francesca Montarolo, et al. Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One. 2014 Sep 29;9(9):e108791.
溶解度数据
In Vitro: DMSO : 100 mg/mL (256.13 mM; Need ultrasonic)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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