LQVTDSGLYRCVIYHPP TFA||-陌孚医药/Medlife

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LQVTDSGLYRCVIYHPP TFA

目录号: PL08407 纯度: ≥99%

LQVTDSGLYRCVIYHPP (LP17) TFA 是一种髓系细胞表达的触发受体 1 (TREM-1) 抑制肽。LQVTDSGLYRCVIYHPP TFA 显著减轻缺血诱导的梗死和神经元损伤。LQVTDSGLYRCVIYHPP TFA 可进入大脑，阻断 TREM-1。

商品编号	规格	价格	会员价
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PL08407-10mg	10mg	¥5143.00	请登录
PL08407-50mg	50mg	询价	询价
PL08407-100mg	100mg	询价	询价

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中文名称	LQVTDSGLYRCVIYHPP TFA
英文名称	LQVTDSGLYRCVIYHPP TFA
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	LQVTDSGLYRCVIYHPP (LP17) TFA 是一种髓系细胞表达的触发受体 1 (TREM-1) 抑制肽。LQVTDSGLYRCVIYHPP TFA 显著减轻缺血诱导的梗死和神经元损伤。LQVTDSGLYRCVIYHPP TFA 可进入大脑，阻断 TREM-1。
生物活性	LQVTDSGLYRCVIYHPP (LP17) TFA is a triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LQVTDSGLYRCVIYHPP TFA substantially alleviates ischemia-induced infarction and neuronal injury. LQVTDSGLYRCVIYHPP TFA can get access into brain and block TREM-1.
性状	Solid
IC50 & Target[1][2]	TREM-1
体外研究(In Vitro)	LQVTDSGLYRCVIYHPP (LP17) (1 or 10?μM; 24 h) substantially decreases mRNA levels of pro-inflammatory cytokines and chemokines after reoxygenation and remarkably attenuates extracellular protein levels of IL-1β and IL-18 in a microglia oxygen-glucose deprivation (OGD) model. LQVTDSGLYRCVIYHPP (LP17) (10 μM; 24 h) interacts with microglial SYK. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	LQVTDSGLYRCVIYHPP (LP17) (0.5 or 1 mg/kg; intranasal; daily for 3 days) alleviates ischemia-induced infarction and neuronal injury in mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
SequenceShortening	LQVTDSGLYRCVIYHPP
参考文献	[1]. Pengfei Xu, et al. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell Death Dis. 2019 Jul 19;10(8):555.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (48.19 mM)H₂O : < 0.1 mg/mL (ultrasonic;adjust pH to 3 with HCl) (insoluble)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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